Burden and Risk Factors for Hospitalization among Staphylococcus aureus Infections in the Southeastern USA Público

Abstract

Background – Staphylococcus Aureus is a common cause of infection both in community and hospital settings but is not extensively characterized. We extrapolated survey data to estimate overall and specific burden of S. aureus infections and estimate exposures associated with S. aureus hospitalization.

Methods – We analyzed a retrospective cohort of cases from the Georgia Emerging Infections Program consisting of cases from Fulton County, GA who had a positive culture of S.aureus in 2017. Cases were identified as invasive (originating from a normally sterile site), sampled 1:1, or non-invasive, sampled 1:4, and specific infection and clinical characteristics were collected. Survey and logistic regression analysis were used to evaluate the incidence of infection and predictors of hospitalization in patients, adjusting for demographic, clinical, and exposure factors.

Results – Incidence of clinically relevant S. aureus infection in 2017 was 405.7 cases per 100,000 people (SE 5.62, range 400.1 - 411.3). Invasive infections of all types had an incidence of 58.5 cases per 100,000 people (SE 2.34). Skin and soft tissue infections (SSTI) were the most common type of infection (225.8 cases per 100,000 people, SE 7.06). Black race, diabetes, MRSA, prior healthcare exposure, prior hospitalization, and homelessness were significant independent predictors of hospitalization across all models.

Conclusions – We found that there was a high incidence of S. aureus infections in Fulton County, GA and determined several independent predictors of hospitalization. Risks associated with prior healthcare exposures should be explored further to determine more specific sources of risk and develop prevention efforts.

Table of Contents

1 -- Distribution Agreement

2 -- Approval Sheet

3 -- Abstract Cover

4 -- Abstract

5 -- Thesis Cover

6 -- Thesis

16 -- Bibliography

18 -- Tables and Figures

About this Master's Thesis

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School	Rollins School of Public Health
Department	Epidemiology
Subfield / Discipline	Epidemiology - MPH & MSPH
Degree	M.P.H.
Submission	Master's Thesis
Language	English
Research Field	Health Sciences, Epidemiology
Palavra-chave	MRSA Disease Surveillance S. Aureus Incidence
Committee Chair / Thesis Advisor	Scott Fridkin, Emory University

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