Burden and Risk Factors for Hospitalization among Staphylococcus aureus Infections in the Southeastern USA Open Access

Phillip, Katherine (Spring 2023)

Permanent URL: https://etd.library.emory.edu/concern/etds/bv73c188f?locale=en


Background – Staphylococcus Aureus is a common cause of infection both in community and hospital settings but is not extensively characterized. We extrapolated survey data to estimate overall and specific burden of S. aureus infections and estimate exposures associated with S. aureus hospitalization.

Methods – We analyzed a retrospective cohort of cases from the Georgia Emerging Infections Program consisting of cases from Fulton County, GA who had a positive culture of S.aureus in 2017. Cases were identified as invasive (originating from a normally sterile site), sampled 1:1, or non-invasive, sampled 1:4, and specific infection and clinical characteristics were collected. Survey and logistic regression analysis were used to evaluate the incidence of infection and predictors of hospitalization in patients, adjusting for demographic, clinical, and exposure factors.

Results – Incidence of clinically relevant S. aureus infection in 2017 was 405.7 cases per 100,000 people (SE 5.62, range 400.1 - 411.3). Invasive infections of all types had an incidence of 58.5 cases per 100,000 people (SE 2.34). Skin and soft tissue infections (SSTI) were the most common type of infection (225.8 cases per 100,000 people, SE 7.06). Black race, diabetes, MRSA, prior healthcare exposure, prior hospitalization, and homelessness were significant independent predictors of hospitalization across all models.

Conclusions – We found that there was a high incidence of S. aureus infections in Fulton County, GA and determined several independent predictors of hospitalization. Risks associated with prior healthcare exposures should be explored further to determine more specific sources of risk and develop prevention efforts.

Table of Contents

1 -- Distribution Agreement

2 -- Approval Sheet

3 -- Abstract Cover

4 -- Abstract

5 -- Thesis Cover

6 -- Thesis

16 -- Bibliography

18 -- Tables and Figures

About this Master's Thesis

Rights statement
  • Permission granted by the author to include this thesis or dissertation in this repository. All rights reserved by the author. Please contact the author for information regarding the reproduction and use of this thesis or dissertation.
Subfield / Discipline
  • English
Research Field
Committee Chair / Thesis Advisor
Last modified

Primary PDF

Supplemental Files