History of Treatment with Antacid Medication Increases Prevalence of Diagnosis of Food Allergy in Children 公开

Abstract

Background: Food allergy affects 6-8% of preschool children, but factors responsible for food allergy in children are poorly understood. Use of antacid medication may be a contributing factor.

Objective: The purpose of this study was to determine if parent-reported antacid medication use was associated with higher prevalence of food allergy in atopic children.

Methods: In this cross-sectional study, parents of children with atopic diseases completed a questionnaire related to treatment a history of treatment with antacid medication and food allergy. Charts were independently reviewed for food specific IgE and/or skin prick test results. Food allergy was defined as a reaction to a food consistent with the anaphylaxis consensus statement and either an elevated food specific IgE or a positive food skin prick test.

Results: 104 questionnaires were completed. Mean age of the participating children was 7.0 ± 4.3 years (Range 5 months to 18 years of age). Fifty-four children (41%) were reported to have taken an antacid medication in the past. History of taking antacid medication was associated with an increased prevalence [57% (27/47) versus 32% (18/57) p 0.008] and higher

prevalence of food allergy of having food allergy [aPR 1.7 (1.1 - 2.5)]. Mean peanut food specific IgE was higher in those with a history of taking antacid medication (11.0 ± 5.0 versus 1.0 ± 5.5 p = 0.01).

Conclusion: History of treatment with antacid medication is associated with an increased Prevalence of having food allergy.

Table of Contents

1. Thesis Pages 8 - 21

2. Tables Pages 22 - 23

3. References Page 24-25

4. Appendix

a. Questionnaire Pages 26

b. SAS Results with annotation Page 27 - 228

About this Master's Thesis

Rights statement

• Permission granted by the author to include this thesis or dissertation in this repository. All rights reserved by the author. Please contact the author for information regarding the reproduction and use of this thesis or dissertation.

School	Rollins School of Public Health
Department	Career Masters of Public Health
Degree	MPH
Submission	Master's Thesis
Language	English
Research Field	Health Sciences, Public Health Health Sciences, Epidemiology
关键词	Antacid medication Children Food Allergy
Committee Chair / Thesis Advisor	Sullivan, Kevin Paul, Emory University
Committee Members	Stecenko, Arlene, Emory University Fitzpatrick, Anne M, Emory University

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