History of Treatment with Antacid Medication Increases Prevalence of Diagnosis of Food Allergy in Children Open Access

DeMuth, Karen (2012)

Permanent URL: https://etd.library.emory.edu/concern/etds/zc77sr03r?locale=en


Background: Food allergy affects 6-8% of preschool children, but factors responsible for food allergy in children are poorly understood. Use of antacid medication may be a contributing factor.

Objective: The purpose of this study was to determine if parent-reported antacid medication use was associated with higher prevalence of food allergy in atopic children.

Methods: In this cross-sectional study, parents of children with atopic diseases completed a questionnaire related to treatment a history of treatment with antacid medication and food allergy. Charts were independently reviewed for food specific IgE and/or skin prick test results. Food allergy was defined as a reaction to a food consistent with the anaphylaxis consensus statement and either an elevated food specific IgE or a positive food skin prick test.

Results: 104 questionnaires were completed. Mean age of the participating children was 7.0 ± 4.3 years (Range 5 months to 18 years of age). Fifty-four children (41%) were reported to have taken an antacid medication in the past. History of taking antacid medication was associated with an increased prevalence [57% (27/47) versus 32% (18/57) p 0.008] and higher

prevalence of food allergy of having food allergy [aPR 1.7 (1.1 - 2.5)]. Mean peanut food specific IgE was higher in those with a history of taking antacid medication (11.0 ± 5.0 versus 1.0 ± 5.5 p = 0.01).

Conclusion: History of treatment with antacid medication is associated with an increased Prevalence of having food allergy.

Table of Contents

1. Thesis Pages 8 - 21

2. Tables Pages 22 - 23

3. References Page 24-25

4. Appendix

a. Questionnaire Pages 26

b. SAS Results with annotation Page 27 - 228

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