Does adjuvant radiation therapy post-surgery result in better survival in Mucosal Melanoma of the Head and Neck (MMHN) at the subsite level? Público

Abstract

Does adjuvant radiation therapy post-surgery result in better survival in Mucosal Melanoma of the Head and Neck (MMHN) at the subsite level?

By Srijana Rajbhandary

Background: Previously conducted studies did not use population based data to explore the difference in survival for mucosal melanoma of the head and neck (MMHN) region at the subsite level among patients receiving surgery alone versus adjuvant radiation post-surgery.

Objectives: To explore whether the 5-year cause-specific survival for MMHN is different for surgery alone compared to adjuvant radiation therapy post-surgery at the subsite level (nasal mucosa, paranasal sinuses, oral cavity, and other sites).

Methods: We conducted a retrospective cohort study on MMHN using population-based Surveillance, Epidemiology, and End Results (SEER) registry data from 2001 to 2009. We used multivariable Cox proportional hazards regression models to compare the 5-year cause-specific survival of MMHN cases at various subsites.

Results: Of the 477 MMHN cases meeting study inclusion criteria, the highest number of cases originated from the nasal cavity (n= 234). There was no statistical evidence to prove a survival advantage of adjuvant radiation therapy post-surgery over surgery alone at any subsite.

Conclusion: In this analysis using population-based cancer registry data, adjuvant radiation therapy post-surgery did not result in improved survival for MMHN at any subsite.

Table of Contents

Contents

I. Literature review 1

II. Introduction 6

III. Methods and materials 7

IV. Statistical analysis 8

V. Results 10

VI. Discussion 12

VII. Recommendations 14

VIII. Tables and graphs 15

IX. References 30

About this Master's Thesis

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School	Rollins School of Public Health
Department	Epidemiology
Degree	MPH
Submission	Master's Thesis
Language	English
Research Field	Health Sciences, Epidemiology
Palavra-chave	SEER mucosal melanoma survival
Committee Chair / Thesis Advisor	Ward, Kevin C., Emory University
Partnering Agencies	Emory University schools, faculty or affiliated programs

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