Age at menarche in relation to oocyte quality and ovarian reserve in young, healthy oocyte donors Público
Hu, Chengcheng (Spring 2023)
Abstract
Introduction. Infertility, defined as the failure to achieve pregnancy after 12 months or more of trying, affects approximately 19% of heterosexual, reproductive-aged women in the United States. Assisted reproductive technologies (ART) such as in vitro fertilization (IVF) are used to address infertility, but live birth rates remain low. The relationship between age at menarche and oocyte quality and ovarian reserve in oocyte donors has not been extensively investigated.
Objective. This study aimed to explore the associations of oocyte donors' age at menarche with ovarian reserve and oocyte quality to better understand potential early-life reproductive factors affecting young-adult fertility parameters.
Methods. A retrospective cohort study was conducted using data from 597 non-identified vitrified oocyte donors who underwent 973 oocyte retrieval cycles at Reproductive Biology Associates (RBA) in Atlanta, GA, USA. Age at menarche (in years) was self-reported and ovarian reserve and oocyte quality were assessed through anti-Müllerian hormone (AMH) levels, antral follicle count (AFC), and the number of total and mature oocytes retrieved per cycle. Generalized estimating equations with Poisson distribution, log link, and robust standard errors were used to estimate the associations of age at menarche with AFC and oocyte counts adjusted for age, BMI, race, year, and education.
Results. The median age of donors was 25 years and 27% were racial/ethnic minorities. There were no statistically significant associations of age at menarche with ovarian reserve and oocyte quality markers, including AMH and AFC, or the number of total or mature oocytes retrieved. For instance, the adjusted AFC was 39.4, 39.2, 38.0, and 38.5 for women with an age at menarche of ≤11, 12, 13, or ≥14 years (p-trend=0.87). Similarly, the adjusted number of mature oocytes retrieved was 25.4, 26.4, 25.3, and 24.9 among women with an age at menarche of ≤11, 12, 13, or ≥14 years (p-trend=0.64).
Conclusion. In our large cohort of young, healthy oocytes donors, age at menarche was not significantly associated with oocyte quality or ovarian reserve.
Table of Contents
1. Abstract
2. Introduction
3. Materials and methods
1) Study design
2) Data collection
3) Statistical analysis
4. Results
1) Demographic Characteristics
2) Ovarian Reserve
3) Outcomes of Controlled Ovarian Stimulation
5. Discussion
6. Conclusion
7. References
8. Appendix
1) Table 1
2) Table 2
3) Table 3
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