Maternal Weight Gain During Pregnancy and Infant Illness 公开

Sappenfield, Olivia Ruth (2012)

Permanent URL: https://etd.library.emory.edu/concern/etds/w95050482?locale=zh
Published

Abstract


Background: Maternal weight gain during pregnancy is a modifiable behavior that has
been linked to adverse pregnancy outcomes. The association between maternal weight
gain and adverse pregnancy outcomes is modified by pre-pregnancy body mass index
(BMI) with women who gain weight within recommendations having better neonatal
outcomes compared to women who gain weight outside recommendations across strata.
The purpose of this study was to examine the association between maternal weight gain
and infant illness.
Methods: Slovak mother and term infant pairs (n=1134) were recruited at delivery and
followed until 16 months. Multiple logistic regression was used to evaluate the
association between maternal weight gain based on the 2009 Institute of Medicine's
recommendations and infant illness (0-16 months) including diarrhea, respiratory disease,
otitis media, and illness requiring antibiotics.
Results: Underweight women gaining weight below recommendations had increased
odds for all outcomes except otitis media (ever sick, adjusted odds ratio [aOR]: 1.45,
95% confidence interval [CI]: 0.40, 5.26) compared to normal weight women who gained
within recommendations, though the results were imprecise. Among normal weight
women, those gaining weight above recommendations had increased odds for all
outcomes except otitis media compared to those gaining weight as recommended (ever
sick, aOR: 1.19, 95% CI: 0.66, 2.17).
Discussion: Our findings suggest maternal weight gain during pregnancy may have
effects in infancy for some outcomes. In particular, infants of underweight women who
gain less weight and infants of normal weight women who gain more weight than
recommended may be at risk for infant illness. Therefore, pregnant women should be
advised to gain weight within recommendations.

Table of Contents

Table of Contents

Chapter I: Background

Literature Review 1

Table 1.1: 2009 Institute of Medicine pregnancy weight gain recommendations, pg. 8

Table 1.2: Studies evaluating the effect of maternal weight gain during pregnancy, pg. 9

Table 1.3: Studies evaluating covariates associated with diarrheal disease, pg. 13

Table 1.4: Studies evaluating covariates associated with respiratory disease, pg. 15

Chapter II: Manuscript

Introduction, pg. 17

Methods, pg. 20

Results, pg. 24

Discussion, pg. 26

References, pg. 30

Tables

Table 2.1: Characteristics of a cohort of Slovak, singleton, live births and their

mothers by pre-pregnancy BMI-specific weight gain category, pg. 37

Table 2.2: Characteristics of a cohort of Slovak, singleton, live births and their

mothers for ever sick by 16 months of age, pg. 39

Table 2.3: Characteristics of a cohort of Slovak, singleton, live births and their

mothers for diarrheal disease by 16 months of age, pg. 40

Table 2.4: Characteristics of a cohort of Slovak, singleton, live births and their

mothers for respiratory disease by 16 months of age, pg. 41

Table 2.5: Characteristics of a cohort of Slovak, singleton, live births and their

mothers for otitis media by 16 months of age, pg. 42

Table 2.6: Characteristics of a cohort of Slovak, singleton, live births and their

mothers for antibiotic use by 16 months of age, pg. 43

Table 2.7: Association between pre-pregnancy specific BMI maternal weight gain

during pregnancy and infant morbidity adjusting for maternal education and

maternal ethnicity, pg. 44

Appendix

IRB Letter of Exemption, pg. 45

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