Exploring Risk Factors for Vitamin D Deficiency in Cystic Fibrosis Patients and Generally healthy Population Público

Abstract

This study is aimed to explore and compare the risk factors of vitamin D deficiency in cystic fibrosis patients and generally healthy population. Our data included 95 cystic fibrosis patients recruited from Emory hospital and Emory clinic, and 719 healthy subjects recruited from Predictive Health Initiative cohort established within the Center for Health Discovery and Well Being. Vitamin D deficiency was defined by the concentration of serum 25[OH]D less than 30 ng/mL. We performed univariate analyses to examine the marginal effect of each potential risks factor on vitamin D deficiency. Multivariate logistic regression models were built subsequently to depict the association between vitamin D deficiency and its significant risk factors. For healthy subjects, the results showed that race other than black, being older, more sun exposure, supplement vitamin D intake, taking physical activity, and lower total body mass are associated with lower risk of vitamin D deficiency. For CF patients, we only identify race and season as important risk factors for vitamin D deficiency and their effects are consistent to those in healthy people. The comparison between the findings based on the CF cohort and those based on the healthy cohort suggests that, the efficient ways to reduce the risk of vitamin D deficiency in healthy subjects, such as increasing sun exposure, taking supplement D with low or middle dose, and lowering the body fat, may not be successful in correcting the low concentration of vitamin D in cystic fibrosis patients. The effective treatment to vitamin D deficiency in CF patients needs to be investigated with further relevant studies.

Table of Contents

Table of Contents 1. Introduction..............................................................1 2. Data and Methods..........................................................6 3. Results of Statistical Analysis for CF Group..............................10 4. Results of Statistical Analysis for Generally healthy Group...............13 5. Results of Statistical Analysis for Combine dataset.......................17 6. Discussion................................................................21 7. Conclusion................................................................27 Reference....................................................................28 Appendix I Tables............................................................35 Appendix II SAS Code.........................................................59

About this Master's Thesis

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School	Rollins School of Public Health
Department	Biostatistics and Bioinformatics
Subfield / Discipline	Biostatistics - MPH & MSPH
Degree	MPH
Submission	Master's Thesis
Language	English
Research Field	Health Sciences, Public Health
Palavra-chave	cystic fibrosis Vitamin D deficiency
Committee Chair / Thesis Advisor	Peng, Limin, Emory University
Committee Members	Liu, Yuan, Emory University
Partnering Agencies	Emory University schools, faculty or affiliated programs

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