Smoking Status and Cutaneous Manifestations Among Patients with Systemic Lupus Erythematosus (SLE) Público
Cleeton, Rebecca (2011)
Published
Abstract
Active smoking is a known risk factor for SLE development and
has also been shown to
cause significant cutaneous damage. In this pilot study we sought
to evaluate the
association between smoking behaviors and the severity of cutaneous
manifestations
among SLE patients. Our cross-sectional study was performed among
lupus clinic
patients, all of whom had a physician's diagnosis of SLE. Patients
were assessed using a
smoking questionnaire along with the Cutaneous Lupus Erythematosus
disease Area and
Severity Index (CLASI). Logistic and ordinal logistic regression
models were used to
estimate potential associations between smoking status and CLASI
scores adjusting for
race, sun exposure, and secondhand smoke. Current smoking status
did not significantly
increase the odds of more severe overall cutaneous manifestations
(OR = 1.421, 95% CI
= 0.408, 4.945), but when the CLASI was stratified into activity
and damage sections,
current smoking status was found to significantly increase the odds
of having active skin
manifestations among patients with SLE (OR = 4.522, 95% CI = 1.066,
19.187).
Table of Contents
Table of Contents
I.
Introduction……………………………………………….………………….1
a.
Lupus……………………………………………………………………...1
b.
Smoking……………………………………………………………….......3
c. Cutaneous Manifestations of
SLE…………………………………….......4
II.
Literature
Review…..………………………………………………..............4
a. Proposed
Mechanism………………………………………………...…....4
b. Cigarette smoking and SLE
meta-analysis…………………………….….6
c. Association between smoking and SLE disease
activity………….……...7
d. Animal
Models………………………………..……………………….....8
e. Association between smoking and cutaneous manifestations of SLE
......9
f. Secondhand
Smoke…………………………………………………......10
g. Specific Aims &
Importance………………………………………....…11
h.
Hypothesis………………………………………………………………11
III.
Methods………………………………………………………………….....12
a. Study
Design……………………………………………………………12
i.
Sample…………………………………………………………..12
ii.
Recruitment……………………………………………………..13
iii. Procedures and
Measures…..……………………………………13
iv.
Confidentiality…………………………………………………..15
v. Informed
Consent…………………………………………….…15
b. Data
Analysis……………………………………………………………16
IV.
Results………………………………..……………………………………..18
V.
Discussion…………………………………….……………………………..20
a.
Response………………………………………………………………....20
b. Interpretation of
Results…………………………………………………21
c. Potential
Bias…………………………………………………………….23
d. Limitations &
Uncertainties……………………………………………...24
VI.
Conclusions…………………….…………………………………………....26
a.
Summary…………………………………………………………………26
b.
Recommendations………………………………………………………..26
VII.
References……………..………………………………………….…………27
VIII. Tables &
Figures…………………………………………………..………..30
IX.
Appendix………………………………………………………………..…...36
About this Master's Thesis
School | |
---|---|
Department | |
Degree | |
Submission | |
Language |
|
Research Field | |
Palavra-chave | |
Committee Chair / Thesis Advisor | |
Committee Members | |
Partnering Agencies |
Primary PDF
Thumbnail | Title | Date Uploaded | Actions |
---|---|---|---|
|
Smoking Status and Cutaneous Manifestations Among Patients with Systemic Lupus Erythematosus (SLE) () | 2018-08-28 13:01:07 -0400 |
|
Supplemental Files
Thumbnail | Title | Date Uploaded | Actions |
---|