Inhibition of Protein Kinase G Facilitates the Consolidation of Fear Extinction Público
Zimmermann, Kelsey Sage (2010)
Published
Abstract
Abstract
Inhibition of Protein Kinase G Facilitates the Consolidation of
Fear Extinction
By Kelsey S. Zimmermann
Previous studies have reported that the activation of PKG by cGMP
is necessary
for the successful acquisition and consolidation of fear memories.
However, little
definitive information is available on whether or not the
acquisition of fear extinction is
similarly affected by exogenously affecting PKG activation. To this
end, we chose to
explore the effect of administering the PKG inhibitor
Rp-8-Br-PET-cGMPS or the PKG
activator 8-Br-cGMP into the basolateral amygdala (BLA) of fear
conditioned mice
immediately after they completed extinction training. When tested
24 hours later, the
animals that received the activator showed extinction levels
similar to vehicle controls,
but those that were given the inhibitor exhibited significantly
less fear to the conditioned
stimulus (CS) when compared to the vehicle group, indicating that
there exists a
facilitatory effect of PKG inhibition on extinction. These data
suggest that PKG
activation may be critical for the maintenance fear memories; that
inhibition of PKG may
be important during the consolidation of extinction of fear; and
that inhibiting PKG might
be a novel therapeutic approach to enhancing extinction in
fear-related disorders.
Table of Contents
Table of Contents
Introduction………………………………………………………….…………..….…1
Methods and
Materials……………………….………………………………………10
Results…………………………………………………………………………………..14
Discussion…………………………………………………………..………………….16
Figure
1……………………………………………………………...………………….22
Figure
2………………………………………………………………………………….23
Figure
3………………………………………………………………………………….24
Figure
4………………………………………………………………………………….25
Figure
5………………………………………………………………………………….26
Figure
6………………………………………………………………………………….27
Figure
7………………………………………………………………………………….28
References…………………………………………………………...………………...29
Appendix...…………………………………………………………...………………...36
About this Honors Thesis
School | |
---|---|
Department | |
Degree | |
Submission | |
Language |
|
Research Field | |
Palabra Clave | |
Committee Chair / Thesis Advisor | |
Committee Members |
Primary PDF
Thumbnail | Title | Date Uploaded | Actions |
---|---|---|---|
|
Inhibition of Protein Kinase G Facilitates the Consolidation of Fear Extinction () | 2018-08-28 12:54:05 -0400 |
|
Supplemental Files
Thumbnail | Title | Date Uploaded | Actions |
---|