The Impact of Rotavirus Vaccine Introduction: An Exploratory Analysis of Case Statistics in Kenya, Zimbabwe and Senegal Público

Abstract

Among diarrheal diseases, rotavirus exhibits a large burden of disease despite the usage and endorsement of safe and effective vaccines. The impact of rotavirus vaccine introduction and usage has been documented by various sources. This paper seeks to demonstrate the various effects of rotavirus vaccine introduction in Kenya, Zimbabwe, and Senegal by examining reported case statistics prior to vaccine introduction, during the year of vaccine introduction, and in the year following vaccine introduction. Vaccine effects such as protection for unvaccinated individuals in populations that have introduced rotavirus vaccine are demonstrated by a 59% case reduction (compared to pre-introduction averages) among unvaccinated 0-1 month olds in the three aforementioned countries combined. Additionally, a simple linear regression model found that on average case ages increased by 12.6 and 12.9 weeks in Kenya and Zimbabwe (respectively) when comparing ages of cases in the three years prior to vaccine introduction to case ages in the year following vaccine introduction. However, in Senegal, cases became 8.1 weeks younger on average in the year following vaccine introduction. These results are largely consistent with previous studies, and despite their limitations, can assist in immunization planning activities. 

Table of Contents

Introduction                                                                                                              1

           

Methods                                                                                                                     5

Results                                                                                                                        8         

Discussion                                                                                                                 14

Conclusion                                                                                                                18

References                                                                                                                 19

About this Master's Thesis

Rights statement

• Permission granted by the author to include this thesis or dissertation in this repository. All rights reserved by the author. Please contact the author for information regarding the reproduction and use of this thesis or dissertation.

School	Rollins School of Public Health
Department	Epidemiology
Subfield / Discipline	Global Epidemiology - MPH & MSPH
Degree	M.P.H.
Submission	Master's Thesis
Language	English
Research Field	Health Sciences, Public Health Health Sciences, Epidemiology
Palavra-chave	Senegal Kenya Rotavirus Immunization Age Shifts Zimbabwe Vaccine Effects
Committee Chair / Thesis Advisor	Lopman, Benjamin, Emory University

Última modificação

Primary PDF

Thumbnail	Title	Date Uploaded	Actions
	The Impact of Rotavirus Vaccine Introduction: An Exploratory Analysis of Case Statistics in Kenya, Zimbabwe and Senegal ()	2019-04-23 13:42:54 -0400	Press to Select an action Download

Supplemental Files

Thumbnail	Title	Date Uploaded	Actions