GABAergic Transmission in the Nucleus Accumbens-Ventral PallidumPath and DRL Task Efficiency in Rats Público

Abstract

Abstract GABAergic Transmission in the Nucleus Accumbens-Ventral Pallidum Path and DRL Task Efficiency in Rats By Marina Georgia Wheeler The nucleus accumbens (NAc) has been implicated in behavioral response inhibition yet the roles of its efferent projections has yet to be explored. One of the major projections from the NAc is to the ventral pallidum (VP). In experiment 1, bilateral VP infusions of the GABAergic antagonist picrotoxin decreased task efficiency in rats on a Differential Reinforcement of Low rates (DRL) 10 second schedule in a dose-dependent fashion. In experiment 2, contralateral disruption of the NAc-VP path via unilateral NAc infusions of muscimol, a GABAergic agonist, and VP infusions of picrotoxin decreased DRL 10 second task efficiency; ipsilateral infusions did not. These findings suggest an intact NAc-VP GABAergic pathway may be involved in behavioral response inhibition as measured by DRL.

Table of Contents

Table of Contents INTRODUCTION........................................................ 1 Behavioral response inhibition..................................... .1 Nucleus Accumbens and Ventral Pallidum........................1 Differential Reinforcement of Low Rates.........................4 Experiment 1............................................................6 Experiment 2............................................................6

METHODS.............................................................. 8 Experiment 1............................................................8 Subjects..................................................................8 DRL 10 second..........................................................9 Training...................................................................9 Surgery..................................................................10 Testing and Intracranial infusions................................11 Histology................................................................12 Statistics and Sensitivity Analyses...............................12 Experiment 2...........................................................13 Subjects................................................................13 DRL 10 second........................................................13 Training.................................................................14

Surgery.................................................................14 Testing and Intracranial Infusions...............................14 Histology................................................................15 Statistics and Sensitivity Analyses...............................15

RESULTS............................................................... 16 Analysis of incomplete data sets..................................16 Experiment 1............................................................18 Histology................................................................18 Responses............................................................. 19 Reinforcements.......................................................22 Task Efficiency........................................................25 Experiment 2..........................................................27 Histology...............................................................27 Responses.............................................................29 Reinforcements......................................................32 Task Efficiency.......................................................35 DISCUSSION........................................................ 38 Poisson Loglinear Analysis.........................................38 Experiment 1.........................................................39 Experiment 2.........................................................40 Interpretations.......................................................42 Conclusions.............................................................47 References........................................................... 48 Appendix A........................................................... 54 Appendix B........................................................... 55

List of Figures Figure 1...............................................................6 Figure 2...............................................................8 Figure 3...............................................................18 Figure 4................................................................21 Figure 5................................................................24 Figure 6................................................................26 Figure 7................................................................28 Figure 8................................................................31 Figure 9................................................................34 Figure 10...............................................................37

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School	Laney Graduate School
Department	Psychology
Subfield / Discipline	Neuroscience and Animal Behavior
Degree	MA
Submission	Dissertation
Language	English
Research Field	Psychology, Psychobiology Biology, Neuroscience Psychology, Physiological
Palabra Clave	Nucleus Accumbens Response Inhibition Ventral Pallidum GABA
Committee Chair / Thesis Advisor	Neill, Darryl B, Emory University
Committee Members	Manns, Joseph, Emory University Bliwise, Nancy, Emory University

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