GABAergic Transmission in the Nucleus Accumbens-Ventral PallidumPath and DRL Task Efficiency in Rats Öffentlichkeit
Wheeler, Marina Georgia (2009)
Abstract
Abstract GABAergic Transmission in the Nucleus Accumbens-Ventral Pallidum Path and DRL Task Efficiency in Rats By Marina Georgia Wheeler The nucleus accumbens (NAc) has been implicated in behavioral response inhibition yet the roles of its efferent projections has yet to be explored. One of the major projections from the NAc is to the ventral pallidum (VP). In experiment 1, bilateral VP infusions of the GABAergic antagonist picrotoxin decreased task efficiency in rats on a Differential Reinforcement of Low rates (DRL) 10 second schedule in a dose-dependent fashion. In experiment 2, contralateral disruption of the NAc-VP path via unilateral NAc infusions of muscimol, a GABAergic agonist, and VP infusions of picrotoxin decreased DRL 10 second task efficiency; ipsilateral infusions did not. These findings suggest an intact NAc-VP GABAergic pathway may be involved in behavioral response inhibition as measured by DRL.
Table of Contents
Table of Contents INTRODUCTION........................................................ 1 Behavioral response inhibition..................................... .1 Nucleus Accumbens and Ventral Pallidum........................1 Differential Reinforcement of Low Rates.........................4 Experiment 1............................................................6 Experiment 2............................................................6
METHODS.............................................................. 8 Experiment 1............................................................8 Subjects..................................................................8 DRL 10 second..........................................................9 Training...................................................................9 Surgery..................................................................10 Testing and Intracranial infusions................................11 Histology................................................................12 Statistics and Sensitivity Analyses...............................12 Experiment 2...........................................................13 Subjects................................................................13 DRL 10 second........................................................13 Training.................................................................14
Surgery.................................................................14 Testing and Intracranial Infusions...............................14 Histology................................................................15 Statistics and Sensitivity Analyses...............................15
RESULTS............................................................... 16 Analysis of incomplete data sets..................................16 Experiment 1............................................................18 Histology................................................................18 Responses............................................................. 19 Reinforcements.......................................................22 Task Efficiency........................................................25 Experiment 2..........................................................27 Histology...............................................................27 Responses.............................................................29 Reinforcements......................................................32 Task Efficiency.......................................................35 DISCUSSION........................................................ 38 Poisson Loglinear Analysis.........................................38 Experiment 1.........................................................39 Experiment 2.........................................................40 Interpretations.......................................................42 Conclusions.............................................................47 References........................................................... 48 Appendix A........................................................... 54 Appendix B........................................................... 55
List of Figures Figure 1...............................................................6 Figure 2...............................................................8 Figure 3...............................................................18 Figure 4................................................................21 Figure 5................................................................24 Figure 6................................................................26 Figure 7................................................................28 Figure 8................................................................31 Figure 9................................................................34 Figure 10...............................................................37
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