Characterization of Kell Glycoprotein Transgenic Mice: Murine Model for Immune Response to Transfusion Öffentlichkeit
Henry, Kate (2011)
Abstract
Abstract
Characterization of Kell Glycoprotein Transgenic Mice: Murine Model
for Immune Response to
Transfusion
By Kate Henry
Mouse models are useful tools to study the generation and effects
of immunity to alloantigens on
transfused and transplanted tissues. However, mouse models are much
more relevant to the
particulars of human biology when they express the human form of
the alloantigens of interest. Our
laboratory generated two strains of transgenic mice, each of which
expresses one of two antithetical
antigens (Cellano and Kell epitopes) from the Kell glycoprotein
blood group system that differ by a
single amino acid (Methionine-Threonine at position 193). The Kell
glycoprotein red blood cell
antigen is one of the most clinically significant antigens in blood
transfusions after ABO and RhD
red blood cell antigens. These Kell glycoprotein transgenic mice,
named Cellano or Kell based on
the variant that they express, are useful models to study immune
responses to transfusion. Here we
describe our initial characterization of these Kell glycoprotein
transgenic mice.
Characterization of Kell Glycoprotein Transgenic Mice: Murine
Model for Immune Response to
Transfusion
By
Kate Henry
B.S. in Biology, Brandeis University, 2009
Advisor: James Zimring, Ph.D., M.D.
A thesis submitted to the Faculty of the
James T. Laney School of Graduate Studies of Emory University
in partial fulfillment of the requirements for the degree of
Master of Science
in Graduate Division of Biological and Biomedical Science,
Immunology and Molecular Pathogenesis
2011
Table of Contents
Table of Contents:
1.
Introduction…………………………………
.1-4
2.
Methods……………………………………...
4-10
3.
Results……………………………………….10-15
4.
Discussion…………………………………...15-21
5. Figure
1……………………………………......22
6. Figure
2……………………………………...23-24
7. Figure
3……………………………………...25-26
8. Figure
4……………………………………….27
9. Figure
5……………………………………….28
10. Figure
6……………………………………...29
11. Figure
7……………………………………...30
12. Figure
8……………………………………...31
13. Figure
9……………………………………...32
14. Figure
10…………………………………….33
15. Figure
11…………………………………….34
16: Figure
12…………………………………….35
17.
References………………………………….36-37
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