Existence of Selective Pressure in G6PD Deficiency alleles on Various African Population Groups Throughout Time Público

Abstract

Glucose-6-phosphate dehydrogenase (G6PD) deficiency is a widespread genetic disorder that affects about 400 million individuals globally. This study explores the historical prevalence of G6PD deficiency and its correlation with different selective pressures from malaria and fava bean consumption by analyzing G6PD deficiency frequency across diverse African populations and periods. Utilizing ancient DNA data, this research seeks to uncover the evolutionary forces that have influenced the distribution of G6PD deficiency. By examining the G6PD gene variants in ancient and present-day populations, the study aims to provide deeper insight into human genetic diversity and the survival advantages conferred by these mutations.

Table of Contents

Introduction - 1

G6PD and G6PD deficiency -1 Malaria and G6PD deficiency -2 Favism and G6PD deficiency -3

Hypothesis/Purpose -3

Method -3

Data Acquisition and Pre-processing -3 Extraction of G6PD regions and Data Categorization -3 Genetic Distance and Linkage Disequilibrium -4

Results -4

PCA Plot Illustrates Temporal Genetic Changes -5 Genetic Distance Between Populations -7 Linkage Disequilibrium and heatmaps -9

Conclusion -12

About this Honors Thesis

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School	Emory College
Department	Biology
Degree	B.S.
Submission	Honors Thesis
Language	English
Research Field	Anthropology, Medical and Forensic Biology, Bioinformatics Biology, Genetics
Palavra-chave	Malaria Favism G6PD deficiency Historic Prevalence Selective Pressure
Committee Chair / Thesis Advisor	Dr. David J. Cutler, Emory University
Committee Members	Dr. John Lindo, Emory University Dr. Skye Comstra, Emory University

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