Predictors of plasma concentrations of polybrominated diphenyl ethers (PBDEs) among pregnant African American women in urban Atlanta: the CHERUB study Público

Abstract

Background: Recent research suggests that prenatal exposure to PBDEs during critical periods of development may impair infant neurodevelopment. Objective: The present study aimed to assess the body burden of PBDEs among pregnant African American women living in urban Atlanta, as well as to examine the predictors of PBDE concentrations in maternal plasma. Method: To date, 108 eligible women have been enrolled in Characterizing Exposures and Outcomes in an Urban Birth Cohort (CHERUB). PBDE concentrations were measured using GC-MS/MS in maternal plasma. We ran univariate and multivariate linear models to assess the relations between demographic, lifestyle and dietary predictors and PBDE concentrations. Results: Only BDE-47, -99 and -100 had frequencies of detection over 50%. The medians (range) were 76.3 (20.7-772.1) pg/mL for BDE-47, 23.8 (< LOD-342.0) pg/mL for BDE-99 and 12.5 (< LOD-289.2) pg/mL for BDE-100. Adjusted for other variables, being married (β=0.38, p<0.01) and action of shaking rug (β =0.57, p<0.01) were predictors for a lower BDE-47 level in maternal plasma; BDE-99 concentration increased with recent consumption of canned meats (β =2.80, p=0.02); while being married (β =0.14, p<0.01) and action of shaking rug (β =0.33, p<0.01) were also inversely associated with BDE-100 concentration, achieving college or equivalent degrees (β =3.02, p=0.02) and recent consumption of canned meats (β =2.45, p=0.08) were found to increase BDE-100 concentration.

Table of Contents

I. Introduction ...................................................................................................................................... 1

II. Method ............................................................................................................................................. 2

Study sample ................................................................................................................................. 2

Biological sample collection and laboratory analysis ...................................................................... 3

Exposure questionnaire data ......................................................................................................... 4

Data analysis ................................................................................................................................. 4

III. Results ............................................................................................................................................. 5

Population characteristics .............................................................................................................. 5

PBDE concentrations in maternal plasma ..................................................................................... 6

Predictors of PBDE concentrations in maternal plasma ................................................................ 6

IV. Discussion ...................................................................................................................................... 7

V. Conclusion ..................................................................................................................................... 11

VI. Reference ...................................................................................................................................... 12

VII. Tables ........................................................................................................................................... 14

About this Master's Thesis

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School	Rollins School of Public Health
Department	Environmental Health
Degree	M.P.H.
Submission	Master's Thesis
Language	English
Research Field	Environmental Health
Palavra-chave	Pregnant women African American PBDEs Predictors
Committee Chair / Thesis Advisor	Barr Dana, Emory University
Committee Members	Paige Tolbert, Emory University
Partnering Agencies	Does not apply (no collaborating organization)

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