Vascular Involvement with Bilateral Connectivity in BOLD and CBV-Weighted Functional Magnetic Resonance Imaging of the Rat Somatosensory System 公开

Varman, Rahul (2012)

Permanent URL: https://etd.library.emory.edu/concern/etds/ft848r27t?locale=zh
Published

Abstract

Abstract


Vascular Involvement with Bilateral Connectivity in BOLD and CBV-Weighted
Functional Magnetic Resonance Imaging of the Rat Somatosensory System


Functional magnetic resonance imaging (fMRI) can reflect measures of brain
activation but can also show discrepencies due to underlying physiological
processes. Previous studies have suggested that vasculature can play a large role in
causing such variance. Scans using different modalities of fMRI such as blood oxygen
level dependent (BOLD) or cerebral blood volume (CBV) can sometimes show
differential results due to the underlying vascular topography. Recent studies have
shown that there exists differential bilateral connectivity in the brain and that BOLD and
CBV-weighted scans register similar patterns showing this pattern, albeit with different
magnitudes. It remains to be examined how underlying vascular profile can affect
bilateral connectivity at different regions of the brain. We compared resting state
bilateral connectivity between various regions associated with the somatosensory system
from both BOLD and CBV acquisitions from 5 rats with vascular density profile
rendered from a functional ultrasound. We observed that there exists a correlation
between how strongly a region of the brain showed bilateral connectivity over time and
the vascular density evident in that region. BOLD and CBV scans showed similar
patterns of activation and connectivity, albeit with different magnitudes as shown
before. We conclude that vasculature may in fact play an important role in bilateral
connectivity in resting state rats. Further experiments should address whether such
correlations exist in other regions of the brain and whether BOLD and CBV continue to
show similar yet different magnitude results.

Table of Contents

Table of Contents

Introduction......................................................................................................................... 1 Background...................................................................................................................... 1 fMRI Modalities............................................................................................................. 2 Rat Experimental Conditions........................................................................................... 3 Methods.............................................................................................................................. 4 Experimental Setup.......................................................................................................... 4 Machine Settings............................................................................................................. 5 Data Analysis.................................................................................................................. 6 Results................................................................................................................................. 8 Activation from Forepaw Stimulation............................................................................. 8 Resting State Symmetry Analysis................................................................................... 8 Vascular Correlation........................................................................................................ 9 Discussion......................................................................................................................... 10 Differences between fMRI Modalities.......................................................................... 10 Variance in Symmetrical Bilateral Connectivity............................................................ 11 Exploring Cerebral Vascular Influences......................................................................... 12 Conclusion......................................................................................................................... 13 Acknowledgements............................................................................................................ 14 Figure 1.............................................................................................................................. 15 Figure 2.............................................................................................................................. 16 Figure 3.............................................................................................................................. 17 Figure 4.............................................................................................................................. 18 Figure 5.............................................................................................................................. 19 Figure 6.............................................................................................................................. 20 Figure 7.............................................................................................................................. 21 Table 1............................................................................................................................... 22 References.......................................................................................................................... 23

About this Honors Thesis

Rights statement
  • Permission granted by the author to include this thesis or dissertation in this repository. All rights reserved by the author. Please contact the author for information regarding the reproduction and use of this thesis or dissertation.
School
Department
Degree
Submission
Language
  • English
Research field
关键词
Committee Chair / Thesis Advisor
Committee Members
最新修改

Primary PDF

Supplemental Files