Vascular Involvement with Bilateral Connectivity in BOLD and CBV-Weighted Functional Magnetic Resonance Imaging of the Rat Somatosensory System Öffentlichkeit
Varman, Rahul (2012)
Published
Abstract
Abstract
Vascular Involvement with Bilateral Connectivity in BOLD and
CBV-Weighted
Functional Magnetic Resonance Imaging of the Rat Somatosensory
System
Functional magnetic resonance imaging (fMRI) can reflect measures
of brain
activation but can also show discrepencies due to underlying
physiological
processes. Previous studies have suggested that vasculature can
play a large role in
causing such variance. Scans using different modalities of fMRI
such as blood oxygen
level dependent (BOLD) or cerebral blood volume (CBV) can sometimes
show
differential results due to the underlying vascular topography.
Recent studies have
shown that there exists differential bilateral connectivity in the
brain and that BOLD and
CBV-weighted scans register similar patterns showing this pattern,
albeit with different
magnitudes. It remains to be examined how underlying vascular
profile can affect
bilateral connectivity at different regions of the brain. We
compared resting state
bilateral connectivity between various regions associated with the
somatosensory system
from both BOLD and CBV acquisitions from 5 rats with vascular
density profile
rendered from a functional ultrasound. We observed that there
exists a correlation
between how strongly a region of the brain showed bilateral
connectivity over time and
the vascular density evident in that region. BOLD and CBV scans
showed similar
patterns of activation and connectivity, albeit with different
magnitudes as shown
before. We conclude that vasculature may in fact play an important
role in bilateral
connectivity in resting state rats. Further experiments should
address whether such
correlations exist in other regions of the brain and whether BOLD
and CBV continue to
show similar yet different magnitude results.
Table of Contents
Table of Contents
Introduction......................................................................................................................... 1 Background...................................................................................................................... 1 fMRI Modalities............................................................................................................. 2 Rat Experimental Conditions........................................................................................... 3 Methods.............................................................................................................................. 4 Experimental Setup.......................................................................................................... 4 Machine Settings............................................................................................................. 5 Data Analysis.................................................................................................................. 6 Results................................................................................................................................. 8 Activation from Forepaw Stimulation............................................................................. 8 Resting State Symmetry Analysis................................................................................... 8 Vascular Correlation........................................................................................................ 9 Discussion......................................................................................................................... 10 Differences between fMRI Modalities.......................................................................... 10 Variance in Symmetrical Bilateral Connectivity............................................................ 11 Exploring Cerebral Vascular Influences......................................................................... 12 Conclusion......................................................................................................................... 13 Acknowledgements............................................................................................................ 14 Figure 1.............................................................................................................................. 15 Figure 2.............................................................................................................................. 16 Figure 3.............................................................................................................................. 17 Figure 4.............................................................................................................................. 18 Figure 5.............................................................................................................................. 19 Figure 6.............................................................................................................................. 20 Figure 7.............................................................................................................................. 21 Table 1............................................................................................................................... 22 References.......................................................................................................................... 23About this Honors Thesis
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