Characteristics of long-term gastric cancer survivors: a population-based SEER analysis Público
Wu, Jiayi (Spring 2019)
Abstract
Background: Gastric cancer (GC) remains the fifth most commonly diagnosed cancer and the third leading cause of cancer death worldwide. Although gastric cancer prognosis remains poor, individual survival time is quite variable. Our aim was to identify demographic, tumor and treatment characteristics associated with long-term overall survival following a gastric cancer diagnosis.
Methods: A population-based retrospective cohort study was conducted using data from patients diagnosed with gastric cancer between 2005 and 2012 registered in the Surveillance, Epidemiology, and End Results (SEER) database (N=43,749). Long-term overall survival was defined as overall survival time ≥ 3 years in our study. Logistic regression analyses was used to estimate the association of each characteristic with long-term survival among all GC patients and patients with advanced stage disease.
Results: A total of 10,715 (24%) patients survived 3 years or longer. Age, race, marital status, urban area, neighborhood poverty, subsite, histological grade, tumor stage and treatment with gastrectomy, radiation and chemotherapy were statistically and independently associated with long-term overall survival following a gastric cancer diagnosis. Age >75 years relative to age <45, married relative to unmarried, urban counties relative to metropolitan areas (OR=0.63, 95% CI=0.45-0.89), overlapping lesion of stomach (OR=0.63, 95% CI=0.45-0.89) relative to cardia, histological grade, and receipt of treatments of gastrectomy, radiation and chemotherapy remained independently and significantly associated with long-term overall survival among GC patients diagnosed with advanced disease.
Conclusion: Our results suggest that long-term gastric cancer survivors have distinct demographic, tumor and treatment characteristics. Age, marital status, urban area, tumor site, histological grade and treatment characteristics were independently and significantly associated with long-term survival among GC patients diagnosed with advanced disease.
Table of Contents
Chapter I: Background 1
1. Overview of Gastric cancer 1
2. Factors associated with gastric cancer survival 1
3. Long-term survival of gastric cancer 4
References 6
Chapter II Manuscript 11
Abstract 11
Introduction 13
Methods 15
Results 17
Discussion 19
Conclusion 22
References 23
Tables 26
Figures 33
Chapter III Summary and possible future directions 34
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