The Impact of Time to Maternal Interview on the Odds of a Negative Response in the National Birth Defects Prevention Study 公开
Gibbs, Cassandra Marie (2011)
Published
Abstract
Objective: To assess whether the time to interview (TTI),
defined as the number of months from
an infant's expected date of delivery (EDD) to a maternal
interview, is associated with the odds
of a negative response when mothers are asked about specific
exposures during pregnancy, and if
so, whether these associations vary by case/control status or
interview quality.
Methods: The National Birth Defects Prevention Study is an
ongoing, population-based case-
control study conducted in ten states. Mothers are interviewed
between six weeks and two years
after the infant's EDD about exposures encountered before and
during pregnancy.
We stratified TTI into four categories: 2-6 months (reference
group), 7-12 months, 13-18
months, and 19-24 months. We examined the following reported
pregnancy experiences as
dichotomous outcomes: upper respiratory infection; kidney, bladder,
or urinary tract infection;
morning sickness/nausea; folic acid-containing vitamin use during
the periconceptional period;
and assisted fertility. Covariates, selected a priori, were case
status, study center, maternal
education, annual family income, year of birth, parity, gestational
age at delivery, birth outcome,
interview quality, and language of interview.
Crude and adjusted odds ratios and 95% confidence intervals were
estimated using
logistic regression. Interaction was assessed for case/control
status and, separately, interview
quality.
Results: Overall, the adjusted odds of a negative response
increased as TTI increased. For each
interview item, the odds of a negative response were greatest for
mothers interviewed 19-24
months after their infant's EDD. Interaction of TTI with
case/control status was observed for
negative reporting of upper respiratory infection, morning
sickness, and folic acid-containing
vitamin use. Adjusted odds of a negative response tended to be
higher in controls than in cases,
and the odds of a negative response increased with TTI in both
cases and controls. There was no
significant interaction by interview quality.
Conclusion: Results from our analysis suggest that TTI
should be considered in case-control
studies of infant outcome that enroll mothers at varying times
after delivery. A sensitivity
analysis can be a good method of assessing whether a study's
conclusions might change based
upon differences in reporting attributable to longer TTIs.
Table of Contents
Table of Contents
Background/Literature Review- 1
Methods- 9
Results- 11
Discussion- 14
Tables- 17
References- 22
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