The Impact of Time to Maternal Interview on the Odds of a Negative Response in the National Birth Defects Prevention Study Público

Abstract

Objective: To assess whether the time to interview (TTI), defined as the number of months from
an infant's expected date of delivery (EDD) to a maternal interview, is associated with the odds
of a negative response when mothers are asked about specific exposures during pregnancy, and if
so, whether these associations vary by case/control status or interview quality.
Methods: The National Birth Defects Prevention Study is an ongoing, population-based case-
control study conducted in ten states. Mothers are interviewed between six weeks and two years
after the infant's EDD about exposures encountered before and during pregnancy.
We stratified TTI into four categories: 2-6 months (reference group), 7-12 months, 13-18
months, and 19-24 months. We examined the following reported pregnancy experiences as
dichotomous outcomes: upper respiratory infection; kidney, bladder, or urinary tract infection;
morning sickness/nausea; folic acid-containing vitamin use during the periconceptional period;
and assisted fertility. Covariates, selected a priori, were case status, study center, maternal
education, annual family income, year of birth, parity, gestational age at delivery, birth outcome,
interview quality, and language of interview.
Crude and adjusted odds ratios and 95% confidence intervals were estimated using
logistic regression. Interaction was assessed for case/control status and, separately, interview
quality.
Results: Overall, the adjusted odds of a negative response increased as TTI increased. For each
interview item, the odds of a negative response were greatest for mothers interviewed 19-24
months after their infant's EDD. Interaction of TTI with case/control status was observed for
negative reporting of upper respiratory infection, morning sickness, and folic acid-containing
vitamin use. Adjusted odds of a negative response tended to be higher in controls than in cases,
and the odds of a negative response increased with TTI in both cases and controls. There was no
significant interaction by interview quality.
Conclusion: Results from our analysis suggest that TTI should be considered in case-control
studies of infant outcome that enroll mothers at varying times after delivery. A sensitivity
analysis can be a good method of assessing whether a study's conclusions might change based
upon differences in reporting attributable to longer TTIs.

Table of Contents

Table of Contents

Background/Literature Review- 1
Methods- 9
Results- 11
Discussion- 14
Tables- 17
References- 22

About this Master's Thesis

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School	Rollins School of Public Health
Department	Epidemiology
Degree	MPH
Submission	Master's Thesis
Language	English
Research Field	Health Sciences, Public Health Health Sciences, Epidemiology
Palabra Clave	birth defects recall case-control interview
Committee Chair / Thesis Advisor	Strickland, Matthew J, Emory University
Committee Members	Tinker, Sarah, National Center on Birth Defects and Developmental Disabilities, CDC
Partnering Agencies	CDC

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