Diagnosis of Latent Tuberculosis Infection among HIV discordant partners using Interferon-Gamma Release Assays (IGRAs). Öffentlichkeit

Talati, Naasha (2011)

Permanent URL: https://etd.library.emory.edu/concern/etds/9p290945b?locale=de
Published

Abstract

ABSTRACT

There is limited data on the effect of HIV status and CD4 counts on performance of Interferon-g Release assays (IGRAs) for diagnosis of latent tuberculosis infection (LTBI).

A cross sectional study was conducted to assess the prevalence of and risk factors for a positive diagnostic test for LTBI, using tuberculin skin test (TST) and IGRAs among HIV-discordant couples in Zambia.

A total of 596 subjects (298couples) were enrolled. Median CD4 count among HIV positive persons was 388 cells/ μl, (range 51-1330). HIV negative persons were more likely than their HIV positive partner, to have a positive diagnostic test for LTBI with TST (203 vs 128), QFT (171 vs 109) and TSPOT (156 vs. 109). On multivariate analysis, HIV negative status was an independent predictor for a positive QFT (OR=2.22, 95% CI 1.42- 3.46) and TSPOT (OR=1.79, 95% CI 1.16-2.77). Among HIV positive subjects a CD4 count >388cells/µl was associated with a positive TST (OR= 1.76 95% CI 1.10-2.82) and QFT (OR=1.71 95% CI 1.06-2.77) but not TSPOT (OR =1.20 95% CI 0.74-1.94).

Persons with HIV had significantly fewer positive diagnostic tests for LTBI with TST, QFT and TSPOT. Persons with a CD4 count <388 cells/µl were less likely to have a positive TST or QFT, but not less likely to have a positive TSPOT. TSPOT may perform better than TST or QFT in HIV positive individuals.

Table of Contents

TABLE OF CONTENTS
Introduction...1
Background...2
Methods...5
Null Hypothesis...5
Patient Selection...5
Sample size calculation...7
Statistical Analysis...7
Results...10
Discussion and Conclusions...13
References...17
Tables...20
Figures...30
Appendix...32

About this Master's Thesis

Rights statement
  • Permission granted by the author to include this thesis or dissertation in this repository. All rights reserved by the author. Please contact the author for information regarding the reproduction and use of this thesis or dissertation.
School
Department
Degree
Submission
Language
  • English
Research Field
Stichwort
Committee Chair / Thesis Advisor
Committee Members
Zuletzt geändert

Primary PDF

Supplemental Files