A Study of Potential Factors that Impact Implantation Rate of Assisted Reproductive Technology Procedures 公开

Bhat, Geeta Lakshmi (2011)

Permanent URL: https://etd.library.emory.edu/concern/etds/9k41zd95w?locale=zh
Published

Abstract

A Study of Potential Factors that Impact Implantation Rate
of Assisted Reproductive Technology Procedures
By Geeta Bhat


Purpose: Assisted Reproductive Technology (ART) procedures are becoming
increasingly popular as an option to overcome infertility. The expense, time, and effort
needed for an ART procedure, however, do not guarantee success. The purpose of the
current study was to identify factors that impact implantation rate, determined by
dividing the total number of fetal hearts detected on an ultrasound by the total number of
embryos transferred per cycle, of ART procedures. ART success can be defined in
various ways. Frequently used ART success measures include singleton pregnancy rate,
multiple pregnancy rate, singleton live birth rate, and multiple live birth rate. Methods:
Logistic regression was used to identify individual factors that were significantly
associated with implantation rate. A multivariate model was constructed using factors
that were significant in bivariate analyses. The factors found to be significant in bivariate
analyses were: maternal age, race, body mass index (BMI), nulligravidas, no prior
spontaneous abortions, reason for ART, treatment protocol, day of embryo transfer,
number of embryos cryopreserved, and use of intracytoplasmic sperm injection (ICSI).
Results: Increasing age, 'other' race, BMI ≥25, and nulligravida, were significantly
associated with decreased odds of obtaining an implantation rate greater than zero. No
prior spontaneous abortions, single male factor as reason for ART, day of embryo
transfer ≥5, and use of ICSI were significantly associated with increased odds of
obtaining an implantation rate greater than zero. Odds of obtaining an implantation rate
greater than zero increased as the number of cryopreserved increased. Compared with
Agonist Suppression+Folicle Stimulating Hormone (FSH), other treatment protocols had
decreased odds of obtaining an implantation rate greater than zero. Conclusions: This
analysis used implantation rate per ART cycle as a measure of success to confirm several
associations noted in previous studies that have used other measures of ART success.

Table of Contents


TABLE OF CONTENTS

INTRODUCTION-----------------------------------------------------------------------------------1

LITERATURE REVIEW------------------------------------------------------------------------------2

METHODS----------------------------------------------------------------------------------------9

RESULTS----------------------------------------------------------------------------------------12

DISCUSSION-------------------------------------------------------------------------------------16

REFERENCES-------------------------------------------------------------------------------------20

TABLES------------------------------------------------------------------------------------------24

APPENDIX A--------------------------------------------------------------------------------------32

About this Master's Thesis

Rights statement
  • Permission granted by the author to include this thesis or dissertation in this repository. All rights reserved by the author. Please contact the author for information regarding the reproduction and use of this thesis or dissertation.
School
Department
Degree
Submission
Language
  • English
Research Field
关键词
Committee Chair / Thesis Advisor
Committee Members
Partnering Agencies
最新修改

Primary PDF

Thumbnail Title Date Uploaded Actions
A Study of Potential Factors that Impact Implantation Rate of Assisted Reproductive Technology Procedures () 2018-08-28 12:27:25 -0400

Supplemental Files

Thumbnail Title Date Uploaded Actions