A Study of Potential Factors that Impact Implantation Rate of Assisted Reproductive Technology Procedures Open Access
Bhat, Geeta Lakshmi (2011)
Published
Abstract
A Study of Potential Factors that Impact Implantation Rate
of Assisted Reproductive Technology Procedures
By Geeta Bhat
Purpose: Assisted Reproductive Technology (ART) procedures
are becoming
increasingly popular as an option to overcome infertility. The
expense, time, and effort
needed for an ART procedure, however, do not guarantee success. The
purpose of the
current study was to identify factors that impact implantation
rate, determined by
dividing the total number of fetal hearts detected on an ultrasound
by the total number of
embryos transferred per cycle, of ART procedures. ART success can
be defined in
various ways. Frequently used ART success measures include
singleton pregnancy rate,
multiple pregnancy rate, singleton live birth rate, and multiple
live birth rate. Methods:
Logistic regression was used to identify individual factors that
were significantly
associated with implantation rate. A multivariate model was
constructed using factors
that were significant in bivariate analyses. The factors found to
be significant in bivariate
analyses were: maternal age, race, body mass index (BMI),
nulligravidas, no prior
spontaneous abortions, reason for ART, treatment protocol, day of
embryo transfer,
number of embryos cryopreserved, and use of intracytoplasmic sperm
injection (ICSI).
Results: Increasing age, 'other' race, BMI ≥25, and
nulligravida, were significantly
associated with decreased odds of obtaining an implantation rate
greater than zero. No
prior spontaneous abortions, single male factor as reason for ART,
day of embryo
transfer ≥5, and use of ICSI were significantly associated
with increased odds of
obtaining an implantation rate greater than zero. Odds of obtaining
an implantation rate
greater than zero increased as the number of cryopreserved
increased. Compared with
Agonist Suppression+Folicle Stimulating Hormone (FSH), other
treatment protocols had
decreased odds of obtaining an implantation rate greater than zero.
Conclusions: This
analysis used implantation rate per ART cycle as a measure of
success to confirm several
associations noted in previous studies that have used other
measures of ART success.
Table of Contents
TABLE OF CONTENTS
INTRODUCTION-----------------------------------------------------------------------------------1
LITERATURE
REVIEW------------------------------------------------------------------------------2
METHODS----------------------------------------------------------------------------------------9
RESULTS----------------------------------------------------------------------------------------12
DISCUSSION-------------------------------------------------------------------------------------16
REFERENCES-------------------------------------------------------------------------------------20
TABLES------------------------------------------------------------------------------------------24
APPENDIX
A--------------------------------------------------------------------------------------32
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