Paleolithic and Mediterranean Diet Pattern Scores and Risk of Incident Colorectal Cancer in Iowa Women, 1986-2012 Open Access

Cheng, En (2017)

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Whereas diet is strongly implicated in the etiology of colorectal cancer (CRC), single dietary constituents tend to be weakly and inconsistently associated with the disease. Dietary patterns may be more helpful for investigating associations of diet with colorectal cancer. Paleolithic and Mediterranean diet pattern scores were previously found to be inversely associated with incident, sporadic colorectal adenoma. To investigate associations of these dietary pattern scores with incident colorectal cancer, we analyzed data from the prospective Iowa Women's Health Study (IWHS). Of the 35,221 56-64 years old women who were cancer-free at baseline, 1,731 developed incident CRC during follow-up. Both diet scores were calculated for each participant and categorized into quintiles, and associations were estimated using Cox proportional hazards models. The multivariable-adjusted hazard ratios comparing persons in the highest quintiles of the Paleolithic and Mediterranean diet scores relative to those in the lowest were 0.99 (95% confidence interval (CI) 0.85, 1.19; Ptrend = 0.85) and 1.01 (95% CI 0.86, 1.18; Ptrend = 0.98), respectively. Our findings suggest that diet patterns that are more Paleolithic- or Mediterranean-like may not be associated with risk for colorectal cancer among older, white women.

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