Synthesis of Diphenylalanine-based Peptide Aldehydes and their Self-Assembly Propensity in a Dynamic Combinatorial Library Public
Zhang, Yusheng (2015)
Published
Abstract
Small peptides with the ability to self-assemble have been investigated both for novel biomaterial discovery purposes and for origins of life research. Diphenylalanine is an example of a small peptide that have been thoroughly studied, and it has been shown to exhibit diverse self-assembly capabilities. Furthermore, chemical modifications that allow each peptide monomer to dynamically link with one another gives the peptide systems even greater possibility to form diverse structures. Inspired by previous studies in the Lynn Lab, this paper discloses the synthesis of diphenylalanine-based peptide aldehydes and discusses the various attributes of the dynamic combinatorial library (DCL) established using the diphenylalanine based peptide aldehydes.
Table of Contents
Introductions 8
Part 1: Synthesizing the Peptides
I. Coupling Amino Acids 15
II. Efforts in procuring Homoserine 17
III. Synthesis, purification, and protection of peptide aldehydes 20
IV. Fmoc removal and further purifications 23
Part 2: Establishing and Characterizing the DCL 25
Conclusion 33
References 35
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