The Drosophila immune response against a natural pathogen, the parasitoid wasp. Pubblico

Keebaugh, Erin Saliba (2013)

Permanent URL: https://etd.library.emory.edu/concern/etds/79407x665?locale=it
Published

Abstract

Drosophila melanogaster has long been a valuable model of innate immunity. The Drosophila humoral innate immune response against opportunistic pathogens has been deeply investigated, and this work has led to a detailed map of innate immunity pathways including Toll, Imd, Jak-Stat, and JNK. However, the Drosophila cellular innate immune response remains to be characterized. Drosophila are hosts to parasitic wasps, which can infect a majority of individuals in natural populations and induce a strong cellular immune response. Thus, we study the Drosophila immune response against parasitic wasps to learn more about the genetics of cellular innate immunity. Additionally, because parasitic wasps are common natural pathogens of Drosophila, we also study the evolution of genes important in the fruitfly immune response against wasps to gain insight into the selective pressures imposed on Drosophila by wasps.

Table of Contents

Table of contents

Chapter 1: The Drosophila immune response against natural pathogens

1-55

Chapter 1: figures

31-34

Chapter 2: Evolution and expression of lectin-24A

56-106

Chapter 2: figures and tables

82-99

Chapter 3: lectin-24A's role in the Drosophila anti-wasp immune response

107-139

Chapter 3: figures and tables

126-133

Chapter 4: edl's role in the Drosophila anti-wasp immune response

140-176

Chapter 4: figures and tables

159-171

Chapter 5: pgant35A's role in the Drosophila anti-wasp immune response

177-197

Chapter 5: figures and tables

188-192

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