The Drosophila immune response against a natural pathogen, the parasitoid wasp. Público
Keebaugh, Erin Saliba (2013)
Abstract
Drosophila melanogaster has long been a valuable model of innate immunity. The Drosophila humoral innate immune response against opportunistic pathogens has been deeply investigated, and this work has led to a detailed map of innate immunity pathways including Toll, Imd, Jak-Stat, and JNK. However, the Drosophila cellular innate immune response remains to be characterized. Drosophila are hosts to parasitic wasps, which can infect a majority of individuals in natural populations and induce a strong cellular immune response. Thus, we study the Drosophila immune response against parasitic wasps to learn more about the genetics of cellular innate immunity. Additionally, because parasitic wasps are common natural pathogens of Drosophila, we also study the evolution of genes important in the fruitfly immune response against wasps to gain insight into the selective pressures imposed on Drosophila by wasps.
Table of Contents
Table of contents
Chapter 1: The Drosophila immune response against natural pathogens
1-55
Chapter 1: figures
31-34
Chapter 2: Evolution and expression of lectin-24A
56-106
Chapter 2: figures and tables
82-99
Chapter 3: lectin-24A's role in the Drosophila anti-wasp immune response
107-139
Chapter 3: figures and tables
126-133
Chapter 4: edl's role in the Drosophila anti-wasp immune response
140-176
Chapter 4: figures and tables
159-171
Chapter 5: pgant35A's role in the Drosophila anti-wasp immune response
177-197
Chapter 5: figures and tables
188-192
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