Strategies to Develop Antibiotics via Diversification from Natural Products 公开

Abstract

Given the recent proliferation of antibiotic-resistant pathogens, there is a profound need for scientific innovation to develop new therapeutics to combat these diseases which were previously thought to have been all but eradicated. I postulate that there are two key problems which must be addressed: in the short-term, chemists must develop antibiotics to which pathogenic bacteria are susceptible. In the long-term, however, there must be a radical shift in infection management and prevention to break the cycle of resistance. A brief survey of diversity-inspired strategies is conducted, and recent efforts in analog development towards establishing a thorough structure-activity relationship around the natural product promysalin are summarized herein.

Table of Contents

Table of Contents and Figures

Chapter 1........................................................................................................................ Page 1

Figure 1.......................................................................................................................... Page 2

Figure 2.......................................................................................................................... Page 3

Figure 3.......................................................................................................................... Page 4

Figure 4.......................................................................................................................... Page 6

Figure 5.......................................................................................................................... Page 8

Figure 6.......................................................................................................................... Page 9

Chapter 2........................................................................................................................ Page 12

Scheme 1........................................................................................................................ Page 13

Scheme 2........................................................................................................................ Page 14

Scheme 3........................................................................................................................ Page 15

Scheme 4........................................................................................................................ Page 15

Scheme 5........................................................................................................................ Page 16

Scheme 6........................................................................................................................ Page 16

Figure 7.......................................................................................................................... Page 17

Chapter 3........................................................................................................................ Page 18

Figure 8.......................................................................................................................... Page 18

Figure 9.......................................................................................................................... Page 19

Scheme 7........................................................................................................................ Page 20

Scheme 8........................................................................................................................ Page 22

Conclusion...................................................................................................................... Page 23

References

Experimental Information...............................................................................................Page 29

About this Master's Thesis

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School	Laney Graduate School
Department	Chemistry
Degree	M.S.
Submission	Master's Thesis
Language	English
Research Field	Chemistry, Organic
关键词	Antibiotics
Committee Chair / Thesis Advisor	William Wuest, Emory University
Committee Members	Frank McDonald, Emory University Nathan Jui, Emory University

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