Strategies to Develop Antibiotics via Diversification from Natural Products 公开

Rossiter, Sean (Fall 2018)

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Given the recent proliferation of antibiotic-resistant pathogens, there is a profound need for scientific innovation to develop new therapeutics to combat these diseases which were previously thought to have been all but eradicated. I postulate that there are two key problems which must be addressed: in the short-term, chemists must develop antibiotics to which pathogenic bacteria are susceptible. In the long-term, however, there must be a radical shift in infection management and prevention to break the cycle of resistance. A brief survey of diversity-inspired strategies is conducted, and recent efforts in analog development towards establishing a thorough structure-activity relationship around the natural product promysalin are summarized herein.

Table of Contents

Chapter 1

Page 1

Figure 1

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Figure 2

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Figure 3

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Figure 4

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Figure 5

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Figure 6

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Chapter 2

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Scheme 1

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Scheme 2

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Scheme 3

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Scheme 4

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Scheme 5

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Scheme 6

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Figure 7

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Chapter 3

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Figure 8

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Figure 9

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Scheme 7

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Scheme 8

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Experimental Information

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