Given the recent proliferation of antibiotic-resistant pathogens, there is a profound need for scientific innovation to develop new therapeutics to combat these diseases which were previously thought to have been all but eradicated. I postulate that there are two key problems which must be addressed: in the short-term, chemists must develop antibiotics to which pathogenic bacteria are susceptible. In the long-term, however, there must be a radical shift in infection management and prevention to break the cycle of resistance. A brief survey of diversity-inspired strategies is conducted, and recent efforts in analog development towards establishing a thorough structure-activity relationship around the natural product promysalin are summarized herein.
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About this Master's Thesis
|Committee Chair / Thesis Advisor|
|Strategies to Develop Antibiotics via Diversification from Natural Products ()||2018-11-09||