Strategies to Develop Antibiotics via Diversification from Natural Products Open Access

Rossiter, Sean (Fall 2018)

Permanent URL: https://etd.library.emory.edu/concern/etds/6w924c92w?locale=en
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Abstract

Given the recent proliferation of antibiotic-resistant pathogens, there is a profound need for scientific innovation to develop new therapeutics to combat these diseases which were previously thought to have been all but eradicated. I postulate that there are two key problems which must be addressed: in the short-term, chemists must develop antibiotics to which pathogenic bacteria are susceptible. In the long-term, however, there must be a radical shift in infection management and prevention to break the cycle of resistance. A brief survey of diversity-inspired strategies is conducted, and recent efforts in analog development towards establishing a thorough structure-activity relationship around the natural product promysalin are summarized herein.

Table of Contents

Chapter 1

Page 1

Figure 1

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Figure 2

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Figure 3

Page 4

Figure 4

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Figure 5

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Figure 6

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Chapter 2

Page 12

Scheme 1

Page 13

Scheme 2

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Scheme 3

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Scheme 4

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Scheme 5

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Scheme 6

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Figure 7

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Chapter 3

Page 18

Figure 8

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Figure 9

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Scheme 7

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Scheme 8

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Conclusion

Page 23

References

Experimental Information

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Page 29

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