Strategies to Develop Antibiotics via Diversification from Natural Products Open Access
Rossiter, Sean (Fall 2018)
Abstract
Given the recent proliferation of antibiotic-resistant pathogens, there is a profound need for scientific innovation to develop new therapeutics to combat these diseases which were previously thought to have been all but eradicated. I postulate that there are two key problems which must be addressed: in the short-term, chemists must develop antibiotics to which pathogenic bacteria are susceptible. In the long-term, however, there must be a radical shift in infection management and prevention to break the cycle of resistance. A brief survey of diversity-inspired strategies is conducted, and recent efforts in analog development towards establishing a thorough structure-activity relationship around the natural product promysalin are summarized herein.
Table of Contents
Table of Contents and Figures
Chapter 1........................................................................................................................ Page 1
Figure 1.......................................................................................................................... Page 2
Figure 2.......................................................................................................................... Page 3
Figure 3.......................................................................................................................... Page 4
Figure 4.......................................................................................................................... Page 6
Figure 5.......................................................................................................................... Page 8
Figure 6.......................................................................................................................... Page 9
Chapter 2........................................................................................................................ Page 12
Scheme 1........................................................................................................................ Page 13
Scheme 2........................................................................................................................ Page 14
Scheme 3........................................................................................................................ Page 15
Scheme 4........................................................................................................................ Page 15
Scheme 5........................................................................................................................ Page 16
Scheme 6........................................................................................................................ Page 16
Figure 7.......................................................................................................................... Page 17
Chapter 3........................................................................................................................ Page 18
Figure 8.......................................................................................................................... Page 18
Figure 9.......................................................................................................................... Page 19
Scheme 7........................................................................................................................ Page 20
Scheme 8........................................................................................................................ Page 22
Conclusion...................................................................................................................... Page 23
References
Experimental Information...............................................................................................Page 29
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