Effects of stress on A-type K+ channel subunit Kv4.2 distribution in the basolateral amygdala 公开

Pang, Fu Wei (2013)

Permanent URL: https://etd.library.emory.edu/concern/etds/5q47rn93q?locale=zh
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Abstract

Potassium channels make up the largest and most diverse class of voltage-gated ion channels in the nervous system. Voltage-gated A-type K+ (Kv) channel subunit Kv4.2 modulates dendritic excitability and synaptic plasticity. As such, voltage-gated channels like Kv4.2 are partially involved in the formation of memory. The basolateral amygdala (BLA) is a recognized locus for pairing of stimuli during fear conditioning. However, little is known about the distribution and function of Kv4.2 in the BLA. Therefore, does Kv4.2 play a role in stress-mediated plasticity in the BLA? We used immunohistochemical techniques at the electron microscopic level to determine the normal distribution of voltage-gated potassium channel subunit Kv4.2 in rat BLA neurons. Additionally, we showed that there was a stress-mediated increase in Kv4.2 localization in dendritic spines. These results suggest a possible compensatory mechanism to decrease pathologic dendritic excitability observed in patients with fear and anxiety disorders.

Table of Contents

TABLE OF CONTENTS

List of figures i

Introduction 1

materials & Methods 4

Results 10

Discussion 16

References 23

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