Effects of stress on A-type K+ channel subunit Kv4.2 distribution in the basolateral amygdala Pubblico

Abstract

Potassium channels make up the largest and most diverse class of voltage-gated ion channels in the nervous system. Voltage-gated A-type K⁺ (Kv) channel subunit Kv4.2 modulates dendritic excitability and synaptic plasticity. As such, voltage-gated channels like Kv4.2 are partially involved in the formation of memory. The basolateral amygdala (BLA) is a recognized locus for pairing of stimuli during fear conditioning. However, little is known about the distribution and function of Kv4.2 in the BLA. Therefore, does Kv4.2 play a role in stress-mediated plasticity in the BLA? We used immunohistochemical techniques at the electron microscopic level to determine the normal distribution of voltage-gated potassium channel subunit Kv4.2 in rat BLA neurons. Additionally, we showed that there was a stress-mediated increase in Kv4.2 localization in dendritic spines. These results suggest a possible compensatory mechanism to decrease pathologic dendritic excitability observed in patients with fear and anxiety disorders.

Table of Contents

TABLE OF CONTENTS

List of figures i

Introduction 1

materials & Methods 4

Results 10

Discussion 16

References 23

About this Honors Thesis

Rights statement

• Permission granted by the author to include this thesis or dissertation in this repository. All rights reserved by the author. Please contact the author for information regarding the reproduction and use of this thesis or dissertation.

School	Emory College
Department	Neuroscience and Behavioral Biology
Degree	BS
Submission	Honors Thesis
Language	English
Research Field	Psychology, General Biology, General Biology, Neuroscience
Parola chiave	Voltage-gated potassium channel Stress Kv4.2 Fear and anxiety disorders Basolateral amygdala
Committee Chair / Thesis Advisor	Muly, E Christopher, Emory University
Committee Members	Lennard, Paul R, Emory University Smith, Yoland, Emory University

Ultima modifica

Primary PDF

Thumbnail	Title	Date Uploaded	Actions
	Effects of stress on A-type K+ channel subunit Kv4.2 distribution in the basolateral amygdala ()	2018-08-28 11:45:16 -0400	Press to Select an action Download

Supplemental Files

Thumbnail	Title	Date Uploaded	Actions