Eating and Substance Use Disorders: The Role of Adverse Mother-Daughter Relationships and the Mu-Opioid Receptor Gene Public

Abstract

Adverse mother-daughter relationships and genetic variation in the mu-opioid receptor gene (OPRM1) have demonstrated associations with both eating disorders and substance use disorders. The present longitudinal study examines the independent and gene-environment interaction effects of an adverse mother-daughter relationship and the presence of the Single Nucleotide Polymorphism (SNP) A118G (rs1799971) in the OPRM1 gene on lifetime severity of substance use and eating disorders in 262 female adolescents. The quality of the mother-daughter relationship was measured using the Five-Minute Speech Sample, the UCLA Life Stress Interview, the Children's Report of Parental Behavior Inventory, and a child-report questionnaire of perceived maternal hostility. The lifetime severities for both disorders were measured using the maximum severity score across age 15 and 20 from the Kiddie-Schedule of Affective Disorders and Schizophrenia for School-Age Children at age 15 and the Structured Clinical Interview for DSM-IV at age 20. Results revealed that the OPRM1 G-allele and child-report measures of mother-daughter relationship quality independently associated with increased lifetime severity of eating disorders. Mother-report measures and a latent variable constructed from both mother-report and child-report measures of mother-daughter relationship, but not the gene, associated with increased lifetime severity of substance use disorders. No gene-environment interaction for either outcome severity was found. Although the findings of the current study are preliminary, they support the role of OPRM1 genetic variation in eating disorder outcomes, and point to the potential for future research to explore differences between child and mother-report of mother-daughter relationship quality that may uniquely associate with the development of eating disorder and substance use disorder outcomes.

Table of Contents

Introduction. 1

Adverse Environments and Development of Eating Disorders. 2

Adverse Environments and Development of Substance Use Disorders. 4

The Reward Pathway. 7

The A118G Polymorphism. 10

Aims and Hypotheses. 13

Methods. 14

Participants. 14

Procedure. 15

Measures. 15

Genotyping. 19

Statistical Analyses. 20

Results. 22

Mother-Daughter Relationship and Child Disorder Outcomes. 22

Genotype and Child Disorder Outcomes. 23

Mother-Daughter Relationship, Genotype, and Child Disorder Outcomes. 24

Supplemental Analyses of Independent Effects. 25

Discussion. 26

Mother-Daughter Relationship and Child Disorder Outcomes. 26

Genotype and Child Disorder Outcomes. 28

Mother-Daughter Relationship, Genotype, and Child Disorder Outcomes. 30

Limitations and Future Directions. 31

References. 35

Tables and Figures. 44

About this Honors Thesis

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School	Emory College
Department	Psychology and Linguistics
Degree	BA
Submission	Honors Thesis
Language	English
Research Field	Psychology, General
Mot-clé	Substance Use Disorders Mother-Daughter Relationship OPRM1 Gene Eating Disorders
Committee Chair / Thesis Advisor	Brennan, Patricia, Emory University
Committee Members	Queen II, Edward L, Emory University Barber, Jessica M, Emory University Wolff, Phillip, Emory University

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