The association between infant visual evoked potentials and the Bayley Scales of Infant Development in Cuernavaca, Mexico Público
Stinger, Amanda Wartner (2012)
Published
Abstract
Abstract
The association between infant visual evoked potentials and
the
Bayley Scales of Infant Development in Cuernavaca, Mexico
Visual evoked potentials (VEPs) have long been used in research,
not only to measure infant
visual acuity, but also to detect underlying differences in brain
development. Little research
has been conducted on how wel flash VEPs actual y correlate with
the widely-used test of
infant development, the Bayley Scales of Infant Development, second
edition (BSID-II). A
secondary analysis was performed on data from a large, double-blind
randomized control ed
trial supplementing pregnant women from 18-22 weeks gestational age
to delivery with 400
mg of daily docosahexaenoic acid (DHA) (n=978 live offspring).
Infant flash VEP testing was
conducted at 3 and 6 months of age, and BSID-II testing performed
at 12 and 18 months of
age. Main predictor and outcome data were available for 686, 825,
760, and 732 infants at
3, 6, 12, and 18 months of age, respectively. Unadjusted linear
regression was significant
for an inverse relationship between N1, P1 and N2 latencies at 3
months and the mental
developmental index (MDI) at 12 months and a positive relationship
between 6-month P1
amplitude and 12-month MDI (all p<0.05). Six month N1 latency
was also positively
associated with MDI at 18 months (p<0.05). Coefficients were
unchanged following
adjustment for infant sex, birth weight, gestational age, home
environment score,
breastfeeding status, maternal schooling or intel igence, or SES.
Using a latency cutoff of the
75th and 90th percentiles, sensitivity of 3-month VEP latencies to
predict MDI at 12 months
ranged from 30.8-36.3% and 15.4-16.5%, respectively; specificity
ranged from 75.7-76.8%
and 90.5-91.4%. Area under the receiver operating characteristic
(ROC) curve for the 3-
month VEP variables to predict 12-month MDI was 0.55-0.57
(p>0.05) and similar for
prediction of 18-month MDI. The data suggest there is not a strong
linear relationship
between 3- and 6-month flash VEPs and the BSID-I at 12 and 18
months. The ROC analysis
suggests the prognostic ability of flash VEPs to predict BSID-I
scores is poor at any threshold.
Table of Contents
Table of Contents
Background . . . . . . . . . . . . . . . . . . . . . . . . . .
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Methods . . . . . . . . . . . . . . . . . . . . . . . . . .
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Results . . . . . . . . . . . . . . . . . . . . . . . . . . . .
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Discussion . . . . . . . . . . . . . . . . . . . . . . . . . .
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Strengths and Limitations . . . . . . . . . . . . . . . . . . . . .
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Future Directions . . . . . . . . . . . . . . . . . . . . . . . . .
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References . . . . . . . . . . . . . . . . . . . . . . . . .
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Tables . . . . . . . . . . . . . . . . . . . . . . . . . . . .
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Figures . . . . . . . . . . . . . . . . . . . . . . . . . . . .
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About this Master's Thesis
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