The association between infant visual evoked potentials and the Bayley Scales of Infant Development in Cuernavaca, Mexico Open Access

Abstract

Abstract

The association between infant visual evoked potentials and the
Bayley Scales of Infant Development in Cuernavaca, Mexico
Visual evoked potentials (VEPs) have long been used in research, not only to measure infant
visual acuity, but also to detect underlying differences in brain development. Little research
has been conducted on how wel flash VEPs actual y correlate with the widely-used test of
infant development, the Bayley Scales of Infant Development, second edition (BSID-II). A
secondary analysis was performed on data from a large, double-blind randomized control ed
trial supplementing pregnant women from 18-22 weeks gestational age to delivery with 400
mg of daily docosahexaenoic acid (DHA) (n=978 live offspring). Infant flash VEP testing was
conducted at 3 and 6 months of age, and BSID-II testing performed at 12 and 18 months of
age. Main predictor and outcome data were available for 686, 825, 760, and 732 infants at
3, 6, 12, and 18 months of age, respectively. Unadjusted linear regression was significant
for an inverse relationship between N1, P1 and N2 latencies at 3 months and the mental
developmental index (MDI) at 12 months and a positive relationship between 6-month P1
amplitude and 12-month MDI (all p<0.05). Six month N1 latency was also positively
associated with MDI at 18 months (p<0.05). Coefficients were unchanged following
adjustment for infant sex, birth weight, gestational age, home environment score,
breastfeeding status, maternal schooling or intel igence, or SES. Using a latency cutoff of the
75th and 90th percentiles, sensitivity of 3-month VEP latencies to predict MDI at 12 months
ranged from 30.8-36.3% and 15.4-16.5%, respectively; specificity ranged from 75.7-76.8%
and 90.5-91.4%. Area under the receiver operating characteristic (ROC) curve for the 3-
month VEP variables to predict 12-month MDI was 0.55-0.57 (p>0.05) and similar for
prediction of 18-month MDI. The data suggest there is not a strong linear relationship
between 3- and 6-month flash VEPs and the BSID-I at 12 and 18 months. The ROC analysis
suggests the prognostic ability of flash VEPs to predict BSID-I scores is poor at any threshold.

Table of Contents

Table of Contents

Background . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1
Methods . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3
Results . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 10
Discussion . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 14
Strengths and Limitations . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 17
Future Directions . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 18
References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 20
Tables . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 22
Figures . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 35

About this Master's Thesis

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School	Rollins School of Public Health
Department	Epidemiology
Subfield / Discipline	Global Epidemiology - MPH & MSPH
Degree	MPH
Submission	Master's Thesis
Language	English
Research Field	Health Sciences, Epidemiology
Keyword	bayley scales of infant development infant development visual evoked potentials
Committee Chair / Thesis Advisor	Stein, Aryeh D, Emory University
Committee Members	Ramakrishnan, Usha, Emory University
Partnering Agencies	Emory University schools, faculty or affiliated programs University, college or educational institution (other than Emory)

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