Autism, lateralization, and handedness: a review of the literature and meta-analysis Öffentlichkeit
Preslar, Jessica Paige (2012)
Abstract
Abstract
Autism, lateralization, and handedness: a review of the literature
and meta-analysis
A number of theories of hemispheric lateralization and autism have
hypothesized a link between the disorder and asymmetries in the
brain. Research has been conducted to investigate this connection,
but different methods and definitions have been used and the
results vary widely. A systematic review and meta-analysis was
conducted to assess the literature on this subject, with the
hypothesis that there would be an association between autism and
laterality that would be moderated by handedness, sex, age, brain
region studied, and level of autism. From a broad search resulting
in 259 papers, 54 were identified for inclusion in the literature
review. This was narrowed further to include only studies reporting
results in the inferior frontal gyrus for a meta-analysis,
resulting in 4 papers. Reviewing the literature found that the
majority of studies found some difference in lateralization between
the autistic and control group, although what the difference was
varied widely. Trends also suggested moderating variables did not
have a strong influence on this relationship, although poor data
quality and underrepresentation of some groups made this difficult
to assess. The meta-analysis also found a moderate but
non-significant effect size of group on lateralization, suggesting
a decrease in the strength of lateralization in the autistic group.
A subgroup analysis of sex and a meta-regression of handedness
showed that these moderating variables did not have a significant
effect on the relationship of autism and lateralization. Although
the results are not conclusive, there appears to be a general trend
towards a relationship between autism and lateralization. However,
more rigorous studies with better controls and clearer reporting of
definitions and results are needed.
Table of Contents
Table of Contents
Introduction...pg 1-5
Methods...pg 5-15
Results...pg 15-22
Discussion...pg 22-34
References...pg 35-41
Appendix A: Variables...pg 42-43
Appendix B: Brain Regions...pg 44
Tables and Figures
Figure 1: Study selection...pg 5
Table 1: Study characteristics...pg 19-20
Figure 2: Summary effect size...pg 20
Figure 3: Publication bias...pg 21
Figure 4: Meta-regression of handedness...pg 22
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