Obesity and 2009 Pandemic Influenza A (H1N1) Público

Revis, Andrew Algimantas (2011)

Permanent URL: https://etd.library.emory.edu/concern/etds/z029p538t?locale=es


Obesity and 2009 Pandemic Influenza A (H1N1)
By Andrew Revis
Many patients with 2009 pandemic influenza A (H1N1) infection were noted to be obese,
however it is not yet clear whether obesity is a an independent risk factor for severe disease.
Using surveillance data, we analyzed demographic and clinical characteristics of Georgia
residents ≥ 20 years of age hospitalized with 2009 H1N1 infection to assess whether obesity was
associated with ICU admission after controlling for demographic factors and comorbidities. In
the multivariate model, a BMI ≥45 was significantly and independently associated with ICU
admission (OR, 2.56; 95% CI 1.02-6.45). Hispanic ethnicity (OR, 3.30; 95% CI 1.28-8.54)
was also found to be independently associated with an increased likelihood of ICU admission
due to 2009 H1N1 infection. Black non-Hispanic race was significantly and inversely associated
with ICU admission (OR, 0.57; 95% CI, 0.34-0.97). The proportion of patients admitted to an
ICU significantly increased with increasing BMI category ( P trend = 0.02). More studies are
needed to clarify which outcomes are related to obesity, and to what extent.

Obesity and 2009 Pandemic Influenza A (H1N1)
Andrew Revis
University of Illinois, Urbana-Champaign
Faculty Thesis Advisor: Dr. Michael Goodman
A thesis submitted to the Faculty of the
Rollins School of Public Health of Emory University
in partial fulfillment of the requirements for the degree of
Master of Public Health
in Epidemiology

Table of Contents

I. Introduction 1-3
II. Methods 4-6
III. Results 7-8
IV. Discussion 9-13
V. References 14-16
VI. Tables 17-20

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