Family Activity Space Overlap as a Risk Factor for Vector-Borne Disease Transmission 公开

Yoshihara, Masato (Spring 2018)

Permanent URL: https://etd.library.emory.edu/concern/etds/xd07gs75z?locale=zh
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Abstract

 

Purpose: Socially structured human movement is key to Aedes aegypti-borne disease (ABD) transmission since it increases the human-mosquito interactions within a narrow space-time window for diseases to be transmitted between the two hosts. Recent theoretical explorations suggest that activity space overlap, specifically amongst those with close social distances (i.e. family members), can drive ABD transmission.

Methods: Using movement survey data collected from families living in three cities in the Yucatan State of Mexico, we aimed to identify family member activity space overlap as a risk factor for ABD transmission. This was accomplished using linear regression models to identify the correlation between the frequency of shared locations amongst families containing members that have acute ABD infection or history of ABD infection with the percent ABD-positive member count in household.

Results: As predicted by mathematical models, empirical analyses indicate that family members have increased risk of ABD contraction with higher degrees of shared activity space with a family member who is either acutely infected with an ABD or has previous ABD history.

Conclusions: These results suggest that there may be an ideal ratio of family activity space overlap that facilitates ABD transmission and persistence within an urban environment. These findings have implications for developing more accurate disease models to aid resource-limited public health programs to efficiently implement vector and disease control.

 

Table of Contents

 

Table of Contents:

Introduction………………………..………………………..………………………..…………..1

Methods………………………..………………………..………………………..………...……..2

            Hypothesis………………………..………………………..………………………..…..2

            Study Area………………………..………………………..………………………..…..3

            Study Design………………………..………………………..………………………....3

            Methods of Data Collection…………………………………………………………….4

            Statistical Analyses………………………..………………………..…………………..5

Results………………………..………………………..………………………..…….…………..6

            Overall Descriptive Statistics…………………………………………………………...6

            Prospective Cohort Descriptive Statistics……………………………………………….6

            Retrospective Cohort Descriptive Statistics…………………………………………….6

            Descriptive Statistics of Prospective Human Movement………………………………..6

            Human Movement Characteristics Analysis..…………………………………………..7

            Activity Space Overlap Analysis………………………………………………………..8

Discussion………………………………………………………………………………………... 8

Conclusions and Recommendations…………………………………………………………... 10

References……………………………………………………………………………………….12

Tables and Figures………………………………………………………………………………15

Appendix………………………………………………………………………………………...35

 

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