Elucidating the role of beta-1-integrin-expressing neurons in corticostriatal regulation of goal-directed behavior 公开
Trinoskey-Rice, Gracy (Summer 2019)
Published
Abstract
Flexible goal-directed behavior can depend on the ability to form action-outcome associations and update these associations in dynamic contexts. Corticostriatal circuits regulate some goal-directed behaviors via orbitofrontal cortex (OFC) modulation of striatal neurons. Meanwhile, b1-integrins are cell adhesion receptors necessary for dendrite and dendritic spine structure and stability. This study aims to elucidate whether b1-integrin-expressing neurons in the OFC regulate goal-directed action via projections to CaMKII-expressing neurons in the dorsomedial striatum (DMS).
Table of Contents
Introduction…………………1
Figures 1-3
Methods…………………….9
Figure 4
Results………………………14
Figures 5 and 6
Discussion………………….16
Conclusion…………………22
References………………….23
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