Elucidating the role of beta-1-integrin-expressing neurons in corticostriatal regulation of goal-directed behavior Open Access

Abstract

Flexible goal-directed behavior can depend on the ability to form action-outcome associations and update these associations in dynamic contexts. Corticostriatal circuits regulate some goal-directed behaviors via orbitofrontal cortex (OFC) modulation of striatal neurons. Meanwhile, b1-integrins are cell adhesion receptors necessary for dendrite and dendritic spine structure and stability. This study aims to elucidate whether b1-integrin-expressing neurons in the OFC regulate goal-directed action via projections to CaMKII-expressing neurons in the dorsomedial striatum (DMS). 

Table of Contents

Introduction…………………1

            Figures 1-3

Methods…………………….9

            Figure 4

Results………………………14

            Figures 5 and 6

Discussion………………….16

Conclusion…………………22

References………………….23

About this Honors Thesis

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School	Emory College
Department	Biology
Degree	B.S.
Submission	Honors Thesis
Language	English
Keyword	decision-making
Committee Chair / Thesis Advisor	Shannon Gourley, Emory University
Committee Members	Kristen Frenzel, Emory University Dieter Jaeger, Emory University Arri Eisen, Emory University

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