ASSOCIATION OF SUCROSE INTAKE WITH INCIDENT COLORECTAL CANCER 公开

Abstract

High sucrose diets are hypothesized to increase colorectal cancer (CRC) risk by several mechanisms; however, sucrose intakes have been inconsistently associated with CRC in human studies.  To investigate associations of sucrose intake with incident CRC, we analyzed data from the prospective Iowa Women’s Health Study of 35,221 cancer-free Iowa women, aged 55 – 69 years old at baseline in 1986. During follow up through 2012, 1,731 women were diagnosed with CRC.  Baseline dietary intakes were assessed with a Willett semiquantitative food frequency questionnaire. Multivariable Cox proportional hazards regression models were used to estimate adjusted hazards ratios (HRs) and their 95% confidence intervals (CI). For those in the highest relative to the lowest intake quintiles, the adjusted HRs (95% CI) for CRC were 1.04 (0.87-1.23; Ptrend = 0.59) for sucrose intake, 1.00 (0.82-1.21; Ptrend = 0.67) for sucrose-containing foods, and 1.01, (0.83-1.22; Ptrend = 0.56) for non-dairy sucrose-containing foods, respectively. These findings did not differ substantially by colorectal site or according to categories of selected participant characteristics.  Our findings do not support that intakes of sucrose or sucrose-containing foods are associated with risk of colorectal cancer among older women.

Table of Contents

Table of Contents

Distribution Agreement

ABSTRACT

INTRODUCTION

METHODS

Study Population and Design

Exposure Assessment

Outcome Assessment

Statistical Analyses

RESULTS

DISCUSSION

REFERENCES

Appendix 1:

About this Master's Thesis

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School	Rollins School of Public Health
Department	Epidemiology
Subfield / Discipline	Epidemiology - MPH & MSPH
Degree	M.P.H.
Submission	Master's Thesis
Language	English
Research Field	Health Sciences, Oncology
关键词	Food frequency questionnaire Sucrose-containing foods
Committee Chair / Thesis Advisor	Roberd M. Bostick, Emory University

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