Associations of polygenic risk score and polybrominated biphenyl exposure on age at menarche in the Michigan polybrominated biphenyl registry Pubblico
Moubadder, Leah (Spring 2020)
Abstract
Numerous small nucleotides polymorphisms and endocrine disrupting chemicals have been associated with changes in the timing of menarche – a complex reproductive event – but, little is known about their interactions. We examined the direct associations of exposure to polybrominated biphenyl (PBB) exposure, an endocrine disruptor, and a previously established polygenic risk score (PRS) with age at menarche and the role of gene-environment interactions. Data from the PBB registry were analyzed (n=219). Age at menarche was obtained by self-reported through a health history questionnaire. We measured PBB levels from whole blood and peripheral blood samples were genotyped and imputed. Linear regression models were used to test the association between PRS and age at menarche, PBB and age at menarche, and investigate effect modification. PRS was positively associated with age at menarche among the total cohort but did not reach statistical significance. PBB was positively associated with age menarche, but only among those exposed to PBB in childhood, and was independent of PRS. Finally, we observed no evidence of gene-environment interaction between PBB exposure and PRS. These data lend support to the hypothesis that age at menarche is a polygenic trait and that timing of menarche is influenced by both environmental and genetic factors.
Table of Contents
Table of Contents
Chapter I: Background………………………………………………………1
Chapter II: Manuscript………………………………………………………5
Introduction………………………………………………………...….5
Methods………………………………………………………….....…..6
Results…………………………………………………………....……11
Discussion……………………………………………………...……..14
References……………………………………………………...……..17
Tables…………………………………………………………....…….22
Figures……………………………………………………………....…25
Chapter III: Summary………………………………………………………26
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Associations of polygenic risk score and polybrominated biphenyl exposure on age at menarche in the Michigan polybrominated biphenyl registry () | 2020-04-29 18:28:17 -0400 |
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