Multi-Trait Polygenic Prediction of Nicotine Dependence translation missing: zh.hyrax.visibility.toc_restricted.text

Abstract

The estimated heritability of nicotine dependence (ND) ranges 40-70%, but Polygenic Risk Scores (PRS) calculated for ND have limited utility using only tobacco use Genome-Wide Association Study (GWAS) summary statistics. We examined a multi-trait PRS model using known genetic correlates of ND liability and show incremental gains in accuracy and power.

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About this Honors Thesis

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School	Emory College
Department	Neuroscience and Behavioral Biology
Degree	B.S.
Submission	Honors Thesis
Language	English
Research field	Biology, Genetics Psychology, Behavioral
关键词	Body Mass Index Educational Attainment Behavioral Genetics Risk-Taking Depression Height Cigarettes per Day Schizophrenia Neuroticism Polygenic Risk Scores Nicotine Dependence
Committee Chair / Thesis Advisor	Dr. Rohan Palmer, Emory University
Committee Members	Dr. Alicia Smith, Emory University Dr. David Weinshenker, Emory University

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