The estimated heritability of nicotine dependence (ND) ranges 40-70%, but Polygenic Risk Scores (PRS) calculated for ND have limited utility using only tobacco use Genome-Wide Association Study (GWAS) summary statistics. We examined a multi-trait PRS model using known genetic correlates of ND liability and show incremental gains in accuracy and power.
Table of Contents
This table of contents is under embargo until 24 May 2021
About this Honors Thesis
|Committee Chair / Thesis Advisor|
|File download under embargo until 24 May 2021||2019-04-08||File download under embargo until 24 May 2021|