Multi-Trait Polygenic Prediction of Nicotine Dependence translation missing: zh.hyrax.visibility.toc_restricted.text

Risner, Victoria (Spring 2019)

Permanent URL: https://etd.library.emory.edu/concern/etds/vm40xs58b?locale=zh
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Abstract

The estimated heritability of nicotine dependence (ND) ranges 40-70%, but Polygenic Risk Scores (PRS) calculated for ND have limited utility using only tobacco use Genome-Wide Association Study (GWAS) summary statistics. We examined a multi-trait PRS model using known genetic correlates of ND liability and show incremental gains in accuracy and power.

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