Fear and safety signal learning and conditioned inhibition using a visual version of the AX+BX- fear-potentiated startle paradigm in monkeys Pubblico

Abstract

Abstract
Fear and safety signal learning and conditioned inhibition using a visual version of the AX+BX-
fear-poteniated startle paradigm in monkeys
By Kimberly B. Schauder
Fear learning and conditioned inhibition have long been studied in animal models to better
understand the behaviors and neurobiology of anxiety disorders. Recently, the conditional
discrimination, or AX+BX-, paradigm has proven consistent and effective across rodent,
nonhuman primate and human species. This study employed a new version of this paradigm, in
which the traditional multimodal cues were replaced by entirely visual cues so that repeated-
measure experimental designs can be possible. Seven rhesus macaques were trained and tested
on at least one set of this strictly visual AX+BX- paradigm. Results showed that this visual
paradigm was comparable to the traditional AX+BX- paradigm in terms of fear and safety signal
learning as well as fear modulation. Additionally, this study provided evidence that this
paradigm can be used across multiple sets and explored the possibility for use of a shortened
training procedure that yields the same results. Future research needs to confirm these
preliminary findings before this paradigm is utilized in longitudinal and developmental studies.

Table of Contents

Table of Contents

Introduction...1
Methods...6
Results...13
Discussion...16
References...26
Tables...28
Table 1: Subject Training Progression
Table 2: Sessions per Learning Phase for each version of AX+BX- Paradigm
Table 3: Log transformed %FPS on Passing Day of Each Learning Phase
Table 4: Paradigm Comparison p values across Three Learning Phases
Table 5: Log transformed %FPS of Various Trial Types on Test Phase
Table 6: Pairwise Comparisons of Various Trial Types on Simple Shapes Paradigm
Test Phase
Table 7: Summary of Results by Subject
Table 8: Log transformed %FPS on Test Phase Across 2 Stimulus Sets
Figures...36
Figure 1: Primate Startle Box
Figure 2: Visual Stimuli
Figure 3: Log transformed %FPS on Passing Day of each Learning Phase
Figure 4: Sessions to Criterion Paradigm Comparisons
Figure 5: Learning Curves for Each Learning Phase
Figure 6: Log transformed %FPS of Various Trial Types on Set 1 Test Phase
Figure 7: Log transformed %FPS of Various Trial Types on Simple Shapes Paradigm Test Phase
Figure 8: Log transformed %FPS on Test Phase Across 2 Stimulus Sets

About this Honors Thesis

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• Permission granted by the author to include this thesis or dissertation in this repository. All rights reserved by the author. Please contact the author for information regarding the reproduction and use of this thesis or dissertation.

School	Emory College
Department	Neuroscience and Behavioral Biology
Degree	BS
Submission	Honors Thesis
Language	English
Research Field	Psychology, Psychobiology Biology, Neuroscience
Parola chiave	Anxiety disorders Fear potentiated startle Conditional Discrimination
Committee Chair / Thesis Advisor	Bachevalier, Jocelyne, Emory University
Committee Members	Buffalo, Elizabeth, Emory University Davis, Michael, Emory University

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