Fear and safety signal learning and conditioned inhibition using a visual version of the AX+BX- fear-potentiated startle paradigm in monkeys Pubblico
Schauder, Kimberly Beth (2011)
Abstract
Abstract
Fear and safety signal learning and conditioned inhibition using a
visual version of the AX+BX-
fear-poteniated startle paradigm in monkeys
By Kimberly B. Schauder
Fear learning and conditioned inhibition have long been studied in
animal models to better
understand the behaviors and neurobiology of anxiety disorders.
Recently, the conditional
discrimination, or AX+BX-, paradigm has proven consistent and
effective across rodent,
nonhuman primate and human species. This study employed a new
version of this paradigm, in
which the traditional multimodal cues were replaced by entirely
visual cues so that repeated-
measure experimental designs can be possible. Seven rhesus macaques
were trained and tested
on at least one set of this strictly visual AX+BX- paradigm.
Results showed that this visual
paradigm was comparable to the traditional AX+BX- paradigm in terms
of fear and safety signal
learning as well as fear modulation. Additionally, this study
provided evidence that this
paradigm can be used across multiple sets and explored the
possibility for use of a shortened
training procedure that yields the same results. Future research
needs to confirm these
preliminary findings before this paradigm is utilized in
longitudinal and developmental studies.
Table of Contents
Table of Contents
Introduction...1
Methods...6
Results...13
Discussion...16
References...26
Tables...28
Table 1: Subject Training Progression
Table 2: Sessions per Learning Phase for each version of AX+BX-
Paradigm
Table 3: Log transformed %FPS on Passing Day of Each Learning
Phase
Table 4: Paradigm Comparison p values across Three Learning
Phases
Table 5: Log transformed %FPS of Various Trial Types on Test
Phase
Table 6: Pairwise Comparisons of Various Trial Types on Simple
Shapes Paradigm
Test Phase
Table 7: Summary of Results by Subject
Table 8: Log transformed %FPS on Test Phase Across 2 Stimulus
Sets
Figures...36
Figure 1: Primate Startle Box
Figure 2: Visual Stimuli
Figure 3: Log transformed %FPS on Passing Day of each Learning
Phase
Figure 4: Sessions to Criterion Paradigm Comparisons
Figure 5: Learning Curves for Each Learning Phase
Figure 6: Log transformed %FPS of Various Trial Types on Set 1 Test
Phase
Figure 7: Log transformed %FPS of Various Trial Types on Simple
Shapes Paradigm Test Phase
Figure 8: Log transformed %FPS on Test Phase Across 2 Stimulus
Sets
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