Childhood Behavior Problems and Prodromal Symptoms in Schizotypal Personality Disorder and 22q11.2 Deletion Syndrome Open Access

Shapiro, Daniel Isaac (2009)

Permanent URL: https://etd.library.emory.edu/concern/etds/tm70mv30s?locale=en
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Abstract


Abstract

Childhood Behavior Problems and Prodromal Symptoms in Schizotypal Personality
Disorder and 22q11.2 Deletion Syndrome

By Daniel I. Shapiro

Adolescents with 22q11.2 Deletion Syndrome (22q11DS) and Schizotypal
Personality Disorder (SPD) are at increased genetic and behavioral risk, respectively, for
the development of psychosis. No published report has directly compared these groups.
Doing so can potentially shed light on the relevance of etiological subtypes in
understanding the pathogenesis of schizophrenia/psychoses.
SPD, 22q11DS, and control participants were administered the Achenbach Child
Behavior Checklist (CBCL) and the Structured Interview for Prodromal Syndromes
(SIPS). Analyses were done with the overall sample of participants, as well as on an age-
, gender-, and ethnicity-matched subsample. On the CBCL, the two high risk groups
demonstrated parallel patterns of score elevations on all scales except the externalizing
factor (including delinquency and aggression), where only the SPD group had higher
scores than controls. On all other scales, the 22q11DS group demonstrated scores
intermediate to those of the SPD and control groups. On the SIPS, both risk groups
showed elevated positive, negative, and disorganized prodromal symptoms with respect
to the control group, but only significantly differed from each other on positive and
negative symptoms. Additionally, approximately 60% of individuals in both groups met
symptom criteria for a prodromal syndrome. Results suggest that these two high risk
groups are more similar than different, and that the SIPS is a valid measure of prodromal
symptoms in 22q11DS.

Table of Contents

Table of contents

INTRODUCTION 1

Schizotypal Personality Disorder as a high-risk Group 5

22q11.2 Deletion Syndrome as a high-risk group 9

Phenotypic Variation in 22q11DS 12

22q11DS and Schizophrenia Symptoms 21

Study Goals and Hypotheses 27

METHOD 31

Participants and Procedure 31

Measures 36

RESULTS 39

SIPS 39

CBCL 45

Prodromal Syndromes 51

DISCUSSION 52

Diagnostic group differences in behavior problems (CBCL) 53

Diagnostic group differences in prodromal symptoms (SIPS) 59

Diagnostic group differences in prodromal syndromes 64

Limitations 66

Summary 67

REFERENCES 69

Table 1 94

Table 2 95

Table 3 96

Table 4 97

Table 5 98

Table 6 99

Table 7 100

Table 8 101

Figure 1 102

Figure 2 103

Figure 3 104

Appendix 1 105

Appendix 2 106

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