Assessing Inspiratory Volume in Adolescents during Physical Activity Open Access

Lopukhin, Anastasia S. (2014)

Permanent URL: https://etd.library.emory.edu/concern/etds/t435gd58d?locale=en
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Abstract

Adolescents are a unique demographic for whom predicting physiological characteristics is difficult. Given their developmental differences from both adults and prepubescent children, making assumptions surrounding certain measures such as heart rate variability and minute ventilation can be challenging. Inspiratory volume is one such uncertain characteristic. At a time when ambient air pollution has become the leading environmental health risk, determining inspiratory volume can give tremendous insight into estimating inhaled pollutant dose. This study tested n=18 adolescent students from an Atlanta area high school to elucidate a relationship between heart rate and inspiratory volume at different levels of physical activity. Inspiratory volume for each breath was measured as participants increased their activity levels from rest to a running sprint on a treadmill. The resulting model that was formulated related the natural logarithm of instantaneous heart rate (lnHR) to the ratio of inspiratory volume (IV) to forced expiratory volume (FVC) in the following manner: IV/FVC= -0.598 + 0.199 (lnHR) (p<0.001, R 2 =0.225). This model can be used in conjunction with ambient air pollution measures to estimate inhaled pollutant dose provided that information about the subject's FVC and heart rate during physical activity are available. This information can further be used to guide policy concerning extracurricular activities in area schools so that adolescents are protected during period of high ambient air pollution while still engaging in physical activities conducive towards promoting and maintaining good health.

Table of Contents

Table of Contents
INTRODUCTION 1
Aims 4
BACKGROUND 4
Particulate Matter 8
Ozone 11
Previous Minute Ventilation Studies 12
RESEARCH METHODS AND DESIGN 14
Subject recruitment 14
Capturing Vital Signs 15
Tidal Volume at Rest 15
Pulmonary Function Test 15
Inspiratory Volume while Active 16
Statistical Analysis 17
RESULTS 18
Study sample 18
Difference between activities 19
Predicted body weight and participant estimated body weight 19
Predicted tidal volume and measured tidal volume 19
Description of collected data 19
Regression model relating inspiratory volume with heart rate 20
DISCUSSION 21
CONCLUSION 24
BIBLIOGRAPHY 25
TABLES AND FIGURES 29
APPENDIX A 37

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