Methods for Evaluating Waning Efficacy of Rotavirus Vaccines Open Access

Abstract

The purpose of this study is to compare four different methods (descriptive method, Durham’s method, Tian’s method and time-dependent covariate method) to detect true waning of rotavirus vaccines efficacy (VE) and to estimate the magnitude of temporal changes in VE. The methods used in this study can be divided into two groups: a descriptive method and methods based on Cox proportional hazard model (Durham’s method, Tian’s method and time-dependent covariate method). We used stochastic agent-based simulation software that generates data from rotavirus VE studies under different scenarios of true VE waning. From the results of these comparisons we conclude that Durham’s method is more powerful in terms of detecting VE waning and providing more information about the temporal behavior of VE. More research is needed to derive better estimates of VE waning.

Table of Contents

Table of Contents

1.   INTRODUCTION

2. MATERIALS AND METHODS

2.1 Simulation model and software

2.2 Descriptive Analysis

2.3 Analytic methods based on the Cox proportional hazard Model

2.3.1 Durham’s Method

2.3.2 Tian’s Method

2.3.3 Time-dependent Covariates Method

3. RESULTS

3.1 Results of MALED

3.2 Comparison between the Descriptive and Durham’s Method for Estimating VE

3.3 Comparison of Estimated Drop in VE per Period between the Descriptive and Durham’s Method

3.4 Comparison of Proportion Rejections of the Null Hypothesis of no VE waning between Durham’s Method, Tian’s Method and Time-dependent Covariates Method

4. DISCUSSION

5. REFERENCE

6. FIGURES AND TABLES

6.1 Tables

6.2 Figures

About this Master's Thesis

Rights statement

• Permission granted by the author to include this thesis or dissertation in this repository. All rights reserved by the author. Please contact the author for information regarding the reproduction and use of this thesis or dissertation.

School	Rollins School of Public Health
Department	Biostatistics
Subfield / Discipline	Biostatistics - MPH & MSPH
Degree	M.S.
Submission	Master's Thesis
Language	English
Research Field	Biology, Biostatistics
Keyword	Waning of Rotavirus Vaccine
Committee Chair / Thesis Advisor	Haber, Michael, Emory University
Committee Members	Lyles, Robert, Emory University

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