The Association Between Antibiotic Treatment and Short-Term Diarrheal Outcomes in Children in Low-Resource Settings Restricted; Files Only
Protil III, Karl (Spring 2023)
Abstract
Objective To study the association between antibiotic treatment and short-term growth, as well as
the association between antibiotic treatment and diarrheal duration among children from birth to
2 years of age in low-resource settings.
Methods Data from the Etiology, Risk Factors, and Interactions of Enteric Infections and
Malnutrition and the Consequences for Child Health (MAL-ED) birth cohort study were
analyzed. Short-term growth was analyzed using linear regression and included 6,600 diarrhea
episodes. Duration was analyzed using survival analysis and included 10,260 diarrhea episodes.
Findings Antibiotic treatment showed no consistent impact on short-term growth. While
antibiotics improved growth for some antibiotic-pathogen pairings, it impaired growth for other
antibiotic-pathogen pairings, including non-bacterial pathogens. Antibiotic treatment consistently
reduced diarrheal duration, including for non-bacterial pathogens.
Conclusion The impact of antibiotics on outcomes for non-bacterial pathogens was unexpected,
as antibiotics reduced duration for viral causes. Antibiotic treatment of some bacteria, such as
Shigella, did not result in an impact on short-term growth, which was unexpected.
Table of Contents
Page 1. Distribution Agreement
Page 2. Approval Sheet
Page 3. Abstract Cover Letter
Page 4. Abstract
Page 5. Thesis Cover Letter
Page 6. Introduction
Page 8. Methods
Page 10. Results
Page 14. Discussion
Page 17. Table 1
Page 18. Table 2
Page 19. Table 3
Page 20. Citations
About this Master's Thesis
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File download under embargo until 18 May 2025 | 2023-04-19 15:46:20 -0400 | File download under embargo until 18 May 2025 |
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