Blood Product Transfusions and Central Line Bloodstream Infections: A retrospective study of transfusions and their relationship to central line bloodstream infections Open Access

Hake, Kristin Nicole (2013)

Permanent URL: https://etd.library.emory.edu/concern/etds/sf2685909?locale=en
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Abstract

Abstract

Blood Product Transfusions and Central Line Bloodstream Infections:

A retrospective study of transfusions and their association with central line bloodstream infections

By Kristin Hake, RN

Central line bloodstream infections (CLABSIs) have been an increasing concern in recent years for hospitals, healthcare providers and patients. While some risk factors in the development of CLABSIs have been identified, limited information on blood product transfusion as a risk has been published. Using data from an existing study on CLABSIs, blood product transfusion information was analyzed to determine if transfusion is associated with an increased risk for development of a CLABSI. In multivariate analysis, transfusion of packed red blood cells and transfusion of any type of blood product was significantly associated with development of a CLABSI (OR=1.96; 95% CI 1.25--3.11) and (OR= 2.71; 95% CI 1.71--4.31 ) respectively, when controlling for short vs. long term period of central line insertion and with receipt of total parenteral nutrition. The risk of CLABSI increased as number of units of PRBCs transfused increased. These results provide insight into the association between blood product transfusions and CLABSIs, however further studies are needed to clarify the relationship.

Table of Contents

List of Tables

  2. Descriptive and Clinical Characteristics of Study Population

  3. Central Line Characteristics of Study Population

  4. Crude Odds Ratios for Blood Product Transfusions

  5. Significant Interaction Terms

  6. Adjusted Odds Ratios for Blood Product Transfusions

  7. Final Multivariate Model

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